Abstract
The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase chain reaction (PCR) to detect HCV-RNA. All serum specimens were negative for anti-c100-3 (or anti-HCV EIA) and HCV PCR. Based on this study, we conclude that HCV does not play a causative or contributing role in the pathogenesis of NASH.
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Rogers, D.W., Lee, C.H., Pound, D.C. et al. Hepatitis C virus does not cause nonalcoholic steatohepatitis. Digest Dis Sci 37, 1644–1647 (1992). https://doi.org/10.1007/BF01299852
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DOI: https://doi.org/10.1007/BF01299852