Abstract
Four days after parturition 17 weeks old rats of Porton Wistar strain were given 8 mg/kg mercury as methylmercury chloride for 5 days. Virgin females or mothers separated from their offspring immediately after delivery received the same treatment and served as controls. Compared with these controls, lactation delayed the onset of weight loss, shortened the time between the end of treatment and the onset of weight gain, accelerated the elimination of mercury from the whole body and prevented the development of severe co-ordination disorders. However, lactation had no detectable effect on the elimination of mercury from the brain. Moreover control and lactating females had the same degree of histological abnormalities both in the granular layer of the cerebellum and in the dorsal root ganglion cells.
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Greenwood MR, Clarkson TW, Doherty RA, Gates AH, Amin-Zaki L, Elhassani S, Majeed MA (1978) Blood clearance half-times in lactating and non-lactating members of a population exposed to methylmercury. Environ Res 16:48–54
Magos L, Clarkson TW (1976) The effect of oral doses of a polythiol resin on the excretion of methylmercury in mice treated with cysteine, D-pencillamine or phenobarbitone. Chem Biol Interact 14:325–335
Magos L, Peristianis GC, Snowden RT (1978) Postexposure preventive treatment of methylmercury intoxication in rats with dimercaptosuccinic acid. Toxicol Appl Pharmacol 45:463–475
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Magos, L., Peristianis, G.C., Clarkson, T.W. et al. The effect of lactation on methylmercury intoxication. Arch Toxicol 45, 143–148 (1980). https://doi.org/10.1007/BF01270912
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DOI: https://doi.org/10.1007/BF01270912