Skip to main content
Log in

Choline acetyltransferase activity in the neurointermediate lobe of the rat pituitary

  • Short Communication
  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

CAT activity was determined in the neurointermediate lobe of the rat's pituitary gland. The level of enzyme activity in the adult rat is of 386.2±39.1 picomoles/hour/neurointermediate lobe. CAT activity is present in the pituitary gland of the newborn animal and increases with age. In organotypic cultured neurointermediates lobes CAT decreases progressively and practically disappears after 10 days.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Bargmann, W.: Neurohypophysial hormones and similar polipeptides. In: Handbook of experimental pharmacology, Vol. XXIII, pp. 1–39 (Berde, B., ed.). Berlin-Heidelberg-New York: Springer. 1968.

    Google Scholar 

  • Brownstein, M., Kobayashi, R., Palkovits, M., Saavedra, J. M.: Choline acetyl transferase levels in diencephalic nuclei of the rat. J. Neurochem.24, 35–38 (1975).

    PubMed  Google Scholar 

  • Cannata, M. A., Tramezzani, J. H.: The neural lobe of the neurohypophysis of the rat: Several types of nerve endings. Experientia25, 1281–1282 (1969).

    PubMed  Google Scholar 

  • Feldberg, W., Vogt, M.: Acetylcholine synthesis in different regions of the central nervous system. J. Physiol.107, 372–381 (1948).

    Google Scholar 

  • Hadley, M. E., Hruby, V. J., Bower, A.: Cellular mechanisms controlling melanophore stimulating hormone (MSH) release. Gen. Comp. Endocr.26, 24–35 (1975).

    PubMed  Google Scholar 

  • Hebb, Catherine: Choline acetylase in the developing nervous system of the rabbit and guinea-pig. J. Physiol.133, 566–570 (1956).

    PubMed  Google Scholar 

  • Hebb, Catherine: Cholinergic neurons in vertebrates. Nature192 (4802), 527–529 (1961).

    PubMed  Google Scholar 

  • Hebb, Catherine: Biosynthesis of acetylcholine in nervous tissue. Physiol. Rev.52, 918–957 (1972).

    PubMed  Google Scholar 

  • Howe, A., Maxwell, D. S.: Electron microscopy of the Pars intermedia of the pituitary gland in the rat. Gen. Comp. Endocr.11, 169–185 (1968).

    PubMed  Google Scholar 

  • Kobayashi, H., Bern, H. A., Nishioka, R. S., Hyoda, V.: The hypothalamohypophysial neurosecretory system of the parakeet. Gen. Comp. Endocr.1, 545–564 (1961).

    PubMed  Google Scholar 

  • Krass, M. E., LaBella, F. S., Shin, S. H., Minnich, J.: Biochemical features of the pineal compared with other endocrine and nervous tissues. Mem. Soc. Endocrinol.19, 49–76 (1971).

    Google Scholar 

  • LaBella, F. S., Shin, S.: Estimation of cholinesterase and choline acetyltransferase in bovine anterior pituitary, posterior pituitary, and pineal body. J. Neurochem.15, 335–342 (1968).

    PubMed  Google Scholar 

  • Lederis, K., Livingston, A.: Neuronal and subcellular localization of acetylcholine in the posterior pituitary of the rabbit. J. Physiol.210, 187–204 (1970).

    PubMed  Google Scholar 

  • Lederis, K., Livingston, A.: Non-neurosecretory nerve endings in the mammalian neurohypophysis. Acta Endocr. (Kbh.) Suppl.119, 98 (1967). 6th Acta Endocrinol. Congress. Abstracts Nℴ 82.

    Google Scholar 

  • Livingston, A., Lederis, K.: Acetylcholine and related enzyme systems in the rabbit neurohypophysis. Acta Endocr. (Kbh.) Suppl.119, 99 (1967). 6th Acta Endocrinol. Congress. Abstract Nℴ 83.

    Google Scholar 

  • McGeer, E. G., Fibiger, H. C., Wickson, V.: Differential development of caudate enzymes in the neonatal rat. Brain Res.32, 433–440 (1971).

    PubMed  Google Scholar 

  • Nakamura, Y., Hassler, R., Kataoka, K., Bak, I. J., Kim, J. S.: Regional distribution of choline acetyltransferase and acetylcholinesterase activity in baboon brain. Folia Psychiat. Neurol. Jap.30 (2), 185–194 (1976).

    PubMed  Google Scholar 

  • Potter, L. T., Murphy, W.: Electrophoresis of acetylcholine, choline and related compounds. Biochem. Pharmacol.16, 1386–1388 (1967).

    PubMed  Google Scholar 

  • Saavedra, J. M., Palkovits, M., Kizer, J. S., Brownstein, M., Zivin, J. A.: Distribution of biogenic amines and related enzymes in the rat pituitary gland. J. Neurochem.25, 257–259 (1975).

    PubMed  Google Scholar 

  • Whitaker, Sharon, LaBella, F. S.: Cholinesterase in the posterior and intermediate lobes of the pituitary. Species differences as determined by light and electron microscopic histochemistry. Z. Zellforsch.142, 69–88 (1973).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gallardo, M.R.G.P., Cannata, M.A. & Tramezzani, J.H. Choline acetyltransferase activity in the neurointermediate lobe of the rat pituitary. J. Neural Transmission 41, 93–98 (1977). https://doi.org/10.1007/BF01252967

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01252967

Keywords

Navigation