Summary
Histamine levels in different regions of the brain in the primateMacaco, Radiata were studied following experimental infarction induced in the basal ganglia by coagulation of the middle cerebral artery. In the basal ganglia an elevation of histamine level was seen probably due to proliferation of mast cells. In the hypothalamus, a main constituent of the ascending histaminergic neuronal pathway, a sharp rise in histamine content occurred in infarcted as well as sham-operated animals: this probably reflects nonspecific stress-related alterations. In contrast, the cortical area of the ischemie hemisphere showed a higher elevation of histamine, demonstrating that infarction in one region can cause widespread specific changes in histaminergic systems remote from the infarct. The rise in histamine level at the ischemie site could evoke an increase in microcirculation which might aggravate cerebral edema, while changes in the remote regions may be responsible for some of the neurological deficits following stroke.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Dismukes, K., Kuhar, M. J., Snyder, S. H. Brain histamine laterations after hypothalamic isolation. Brain Research78, 144–151 (1974).
Edvinnson, L., Mac Kenzie, E. T. Amine mechanisms in cerebral circulation. Pharmacol. Rev.28, 275–347 (1977).
Hayakawa, T., Waltz, A. G. Immediate effects of cerebral ischemia evolution and resolution of neurological deficits after experimental occlusion of one middle cerebral artery in conscious cats. Stroke6, 321–327 (1975).
Jellinger, K., Riederer, P. Brain monoamines in metabolic coma and stroke. Adv. Neurol.20, 535–546 (1978).
Jellinger, K., Riederer, P., Kothbauer, P. Changes in some putative neurotransmitters in human cerebral infarction. J. Neural Transm., Suppl. 14, pp. 31–44. Wien-New York: Springer. 1978 a.
Jellinger, K., Riederer, P., Kothbauer, P. P. Brain monoamines in human cerebral infarcts. Acta Neuropath. (Berlin)41, 173–176 (1978 b).
Kablson, G., Rosengren, E. New approaches to the physiology of histamine. Physiol. Rev.48, 155–196 (1968).
Kogure, K., Scheinberg, P., Kishikawa, H., Busto, R. The role of monoamines and cyclic AMP in ischemie brain edema. In: Dynamics of Brain Edema (Pappius, H. H., Feindell, W. M., eds.), pp. 203–214. Berlin-Heidelberg-New York: Springer. 1976.
Lorenz, W., Reimann, H., Bartk, J., Kusche, R., Meyer, A., Donicke, A., Hutzel, M. A sensitive and specific method for the determination of histamine in human whole blood and plasma, Hoppe Seyler's Z. Physiol. Chem.353, 911–920 (1972).
Moskowitz, M. A., Wurtman, R. J. Acute stroke and brain monoamines. In: Cerebrovascular Diseases (Scheinberg, P., ed.), pp. 153–166. New York: Raven Press. 1976.
Mrsulja, B. B., Lust, W. D., Mrsulja, B. J., Passonnaeau, J. V. Effect of repeated cerebral ischemia on metabolites and metabolic rate in gerbil cortex. Brain Research119, 480–486 (1977).
Mrsulja, B. B., Mrsulja, B. J., Spatz, M., Ito, U., Walker, J. T., jr., Klatzo, I. Experimental cerebral ischemia in mongolian gerbils. IV. Behavior of biogenic amines. Acta Neuropathol. (Berlin)36, 1–8 (1976 a).
Mrsulja, B. B., Mrsulja, B. J., Spatz, M., Klatzo, I. Monoamines in cerebral ischemia in relation to brain edema. In: Dynamics of Brain Edema (Pappius, H. H., Feindell, W. M., eds.), pp. 187–192. Berlin-Heidelberg-New York: Springer. 1976 b.
O'Brien, M. D., Waltz, A. G., Jordan, M. M. Ischemie cerebral edema. Arch. Neurol.30, 456–462 (1974).
Riederer, P., Jellinger, K. Brain monoamines in cerebral infarction and coma. In: Pathophysiology of Cerebral Energy Metabolism (Mrsulja, B. B., Rukic, Lj. M., eds.), pp. 121–141. New York: Plenum Publishing Corporation. 1979.
Robinson, R. G., Shoemaker, W. J., Schlumpf, M. Time course of changes in catecholamines following right hemispheric cerebral infarction in the rat. Brain Research18, 202–208 (1980).
Schwartz, J. C., Barbin, G., Baudry, M., Garbarg, M., Martres, M. P., Pollard, H., Verdiere, M. Metabolism and functions of histamine in the brain. Curr. Dev. Psychopharmacol.5, 173–261 (1979).
Subramanian, N., Schinzel, W., Mitznegg, P., Estler, C. J. Regional levels of histamine in rat brain after microwave irradiation: Evidence for artifacts in the enzymatic-isotopic assay. Agents and Actions8, 488–490 (1978).
Subramanian, N., Mulder, A. H. Modulation by histamine of the efflux of radiolabeled catecholamines from rat brain slices. Eur. J. Pharmacol.43, 143–152 (1977).
Subramanian, N. Depletion of noradrenaline in the rat brain by histamine. Ind. J. Pharmacol.11, 177–180 (1979).
Theodore, D., Abraham, J. A sequential study of capillaries in the infarcted area of primate brain. Ind. J. Med. Res.71, 821–828 (1980).
Welch, K. M. A., Chabi, E., Dodson, R. F., Wong, T. P. F., Nell, J., Bergin, B. The role of biogenic amines in the progression of cerebral ischemia and edema. In: Dynamics of Brain Edema (Pappius, H. H., Feindell, W. M., eds.), pp. 193–202. Berlin-Heidelberg-New York: Springer. 1976.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Subramanian, N., Theodore, D. & Abraham, J. Experimental cerebral infarction in primates: Regional changes in brain histamine content. J. Neural Transmission 50, 225–232 (1981). https://doi.org/10.1007/BF01249144
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01249144