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Hydroxyindole-O-methyl-transferase activity in the pineal gland of the rabbit

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Summary

Rabbit pineal HIOMT activity shows a diurnal rhythm. The highest values are observed at night and the lowest during the daytime.

Animals kept in permanent darkness show higher values than those in constant light. Bilateral superior cervical ganglionectomy results in a tenfold decrease in pineal HIOMT activity.

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References

  • Axelrod, J., R. J. Wurtman, andS. H. Snyder: Control of Hydroxyindole-O-Methyl-transferase activity in the rat pineal gland by environmental lighting. J. Biol. Chem.240, 949–954 (1965).

    Google Scholar 

  • Axelrod, J.: Neural control of indoleamine metabolism in the pineal. In: Ciba Foundation Symposium on The Pineal Gland (Wolstenholme, G. E. W., andJ. Knight, eds.), pp. 35–52. Edinburgh-London: Churchill Livingstone. 1971.

    Google Scholar 

  • Eichler, V. B., andR. Y. Moore: Pineal Hydroxyindole-O-methyl-transferase and gonadal responses to blinding or continuous darkness blocked by pineal denervation in the male hamster. Neuroendocrinology8, 81–85 (1971).

    Google Scholar 

  • Kappers, J. A.: The pineal organ: an introduction. In: Ciba Foundation Symposium (Wolstenholme, G. E. W., andJ. Knight, eds.), pp. 3–34. Edinburgh-London: Churchill Livingstone. 1971.

    Google Scholar 

  • Keuls, M.: Quoted bySnedecor, G. W., andW. G. Cochran in: Statistical Methods. The Iowa State University Press. 1956.

  • Klein, D. C., andJ. L. Weller: Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Science169, 1093–1095 (1970).

    Google Scholar 

  • Lynch, H. J.: Diurnal oscillations in pineal melatonin content. Life Sci.10, 791–795 (1971).

    Google Scholar 

  • Lynch, H. J., andR. J. Wurtman: Quoted byCardinali, D. P., andR. J. Wurtman. In: Pineal Physiology (Altschule, M. D., ed.). Harvard University Press. 1973.

  • Moore, R.: Pineal response to light: mediation by the accesory optic system in the monkey. Nature222, 781–782 (1969).

    Google Scholar 

  • Moore, R. Y., andR. L. Rapport: Pineal and gonadal function in the rat following cervical sympathectomy. Neuroendocrinology7, 361–374 (1971).

    Google Scholar 

  • Nagle, C. A., D. P. Cardinali, andJ. M. Rosner: Light regulation of rat retinal Hydroxyindole-O-methyl-transferase (HIOMT) activity. Endocrinology91, 423–426 (1972).

    Google Scholar 

  • Nagle, C. A., D. P. Cardinali, andJ. M. Rosner: Retinal and pineal Hydroxyindole-O-methyl-transferase in the rat: changes following cervical sympathectomy, pinealectomy or blinding. Endocrinology92, 1560–1564 (1973).

    Google Scholar 

  • Romijn, H. J.: Parasympathetic innervation of the rabbit pineal gland. Brain Res.55, 431–436 (1973).

    Google Scholar 

  • Wurtman, R. J., J. Axelrod, andJ. E. Fischer: Melatonin synthesis in the pineal gland: effect of light mediated by the sympathetic nervous system. Science143, 1328–1329 (1964).

    Google Scholar 

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de Gallardo, M.R.G.P., Tramezzani, J.H. Hydroxyindole-O-methyl-transferase activity in the pineal gland of the rabbit. J. Neural Transmission 36, 51–57 (1975). https://doi.org/10.1007/BF01243437

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  • DOI: https://doi.org/10.1007/BF01243437

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