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Zum Wirkungsmechanismus fördernder oder hemmender Faktoren bei Virusinfekten, insbesondere der Poliomyelitis

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Zusammenfassung

Die fördernden (provozierenden) und hemmenden (interferierenden) Faktoren bei der Poliomyelitis und anderen Virusinfektionen des ZNS werden kurz besprochen. Unter den theoretisch möglichen Wirkungsmechanismen ist die Förderung der Multiplikation des Virus durch die provozierenden Reize der wahrscheinlichste.

Die Analyse der provozierenden Faktoren zeigt, daß sie auf neurogenem oder humoralem Wege (via Hydrocortison) oder auf beiden Wegen den Protein- und Nucleinsäurestoffwechsel der Zellen stimulieren. Es wird als Arbeitshypothese angenommen, daß hierin der gemeinsame Wirkungsmechanismus der Provokationsreize zu suchen ist, da in einer virusinfizierten Zelle das Virus die Spezifität der synthetisierten Nucleinsäuren und Proteine weitgehend determiniert.

Gestützt wird diese Annahme durch die Tatsache, daß Zellen, die in ihrem Zellstoffwechsel geschädigt sind, zur Virusmultiplikation nicht in der Lage sind.

Summary

  1. 1.

    There are several well known factors which may provoke paralysis in poliomyelitis. On the other hand, there are factors which protect infected animals from virus inducced paralysis or protect nerve cells from destruction.

  2. 2.

    The analysis of the provoking factors shows that all of them comprise neural and/or hormonal (Hydrocortisone) stimuli for the protein and nucleic acid metabolism of nerve cells. Considering that in virus infected cells the specifity of the products of nucleic acid and protein synthesis are, at least partially, determined by the infecting virus, it seems to be a useful working hypothesis, that the stimulation of these metabolic pathways is the common mechanism of the provoking factors.

  3. 3.

    On the other hand the analysis of the factors interfering with virus multiplication shows that all of them induce a heavy damage of the nucleic acid and of the protein metabolism of the nerve cells.

Résumé

  1. 1.

    Ils existent plusieurs facteurs bien connus, qui provoquent une paralysie poliomyélitique. Mais de l'autre côté il y a des facteurs, qui protectent les animaux infectés de la paralysie vireuse ou les cellules nerveuses de la destruction.

  2. 2.

    L'analyse des agents provocateurs montre que tous comprennent les stimuli nerveux et hormonaux (Hydrocortisone) pour le métabolisme protéique et pour les acides nucléiques des cellules nerveuses. Considérant la spécificité des produits des acides nucléiques et de la synthèse protéique dans les cellules infectées, — qui est au moins partiellement déterminée par l'infection vireuse, — il semble d'être une hypothèse utile de travail, que la stimulation des ces fonctions métaboliques est le mécanisme vireux des agents provocateurs.

  3. 3.

    De l'autre côté l'analyse des facteurs qui interfèrent avec la multiplication du virus montre que leur totalité provoque une lésion grave des acides nucléiques et du métabolisme des cellules nerveuses.

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    Gerd Poetschke

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Poetschke, G. Zum Wirkungsmechanismus fördernder oder hemmender Faktoren bei Virusinfekten, insbesondere der Poliomyelitis. Acta Neurovegetativa 15, 486–527 (1957). https://doi.org/10.1007/BF01234622

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