Skip to main content
SpringerLink
Log in

Chromosomal localization of the gene for human B-cell antigen CD40

  • Brief Communication
  • Published:
Somatic Cell and Molecular Genetics

Abstract

CD40 is a surface glycoprotein expressed on all human B lymphocytes and plays an important role in B-cell development, growth, and differentiation. Anti-CD40 monoclonal antibodies cause isotype switching in B cells treated with IL-4. CD40 is a member of a family of proteins that include low-affinity nerve growth factor receptor, TNF receptor, and the antigen Fas. The ligand for CD40 had been recently identified and has been assigned to the X chromosome. Using a panel of human-rodent somatic cell hybrids, we now show that CD40 maps to human chromosome 20.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literature cited

  1. Paulie, S., Ehlin-Henriksson, B., Mellstedt, H., Koho, H., Aissa, H.B., and Perlmann, P. (1985).Cancer Immunol. Immunother. 2023–30.

    PubMed  Google Scholar 

  2. Ledbetter, J.A., Shu, G., Gallagher, M., and Clark, E.A. (1987).J. Immunol. 138788–794.

    PubMed  Google Scholar 

  3. Liu, Y.-J., Joshua, D.E., Williams, G.T., Smith, C.A., Gordon, J., and MacLennan, I.C.M. (1989).Nature 342929–931.

    PubMed  Google Scholar 

  4. Liu, Y.-J., Mason, D.Y., Johnson, G.D., Abbot, S., Gregory, C.D., Hardie, D.L., Gordon, J., and MacLennan, I.C.M. (1991).Eur. J. Immunol. 211905–1910.

    PubMed  Google Scholar 

  5. Clark, E.A., and Ledbetter, J.A. (1986).Proc. Natl. Acad. Sci. U.S.A. 834494–4498.

    PubMed  Google Scholar 

  6. Braesch-Andersen, S., Paulie, S., Koho, H., Nika, H., Aspenström, P., and Perlmann, P. (1989).J. Immunol. 142562–567.

    PubMed  Google Scholar 

  7. Vallé, A., Zuber, C.E., Defrance, T., Djossou, O., Rie, M.D., and Banchereau, J. (1989).Eur. J. Immunol. 191463–1467.

    PubMed  Google Scholar 

  8. Banchereau, J., de Paoli, P., Valle, A., Garcia, E., and Rousset, F. (1991).Science 25170–72.

    PubMed  Google Scholar 

  9. Shapira, S.K., Vercelli, D., Jabara, H.H., Fu, S.M., and Geha, R.S. (1992).J. Exp. Med. 175289–292.

    PubMed  Google Scholar 

  10. Stamenkovic, I., Amiot, M., Pesando, J.M., and Seed, B. (1989).Cell 561057–1062.

    PubMed  Google Scholar 

  11. Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., and Nagata, S. (1991).Cell 66233–243.

    PubMed  Google Scholar 

  12. Fuleihan, R., Ramesh, N., Loh, R., Jabara, H., Rosen, F.S., Chatila, T., Fu, S.M., Stamenkovic, I., and Geha, R.S. (1993).Proc. Natl. Acad. Sci. U.S.A. (in press).

  13. Aruffo, A., Farrington, M., Hollenbaugh, D., Li, X., Milatovich, A., Nonoyama, S., Bajorath, J., Grosmaire, L.S., Stenkamp, R., Neubauer, M., Roberts, R.L., Noelle, R.J., Ledbetter, J.A., Francke, U., and Ochs, H.D. (1993).Cell 72291–300.

    PubMed  Google Scholar 

  14. Allen, R.C., Armitage, R.J., Conley, M.E., Rosenblatt, H., Jenkins, N.A., Copeland, N.G., Bedell, M.A., Edelhoff, S., Disteche, C.M., Simoneaux, D.K., Fanslow, W.C., Belmont, J., and Spriggs, M.K. (1993).Science 259990–993.

    PubMed  Google Scholar 

  15. Korthauer, U., Graf, D., Mages, H.W., Briere, F., Padayachee, M., Malcolm, S., Ugazio, A.G., Notarangelo, L.D., Levinsky, R.J., and Kroczek, R.A. (1993).Nature 361539–541.

    PubMed  Google Scholar 

  16. DiSanto, J.P., Bonnefoy, J.Y., Gauchat, J.F., Fischer, A., and de Saint Basile, G. (1993).Nature 361541–543.

    PubMed  Google Scholar 

  17. Pelletier, J., Brook, D.J., and Housman, D.E. (1991).Genomics 101079–1082.

    PubMed  Google Scholar 

  18. Geissler, E.N., Liao, M., Brook, D.J., Martin, F.H., Zsebo, K.M., Housman, D.E., and Galli, S.J. (1991).Somat. Cell Mol. Genet. 17207–214.

    PubMed  Google Scholar 

  19. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning, (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York), pp. 9.16–9.19.

    Google Scholar 

  20. Finberg, A.P., and Vogelstein, B. (1983).Anal. Biochem. 137266–267.

    Google Scholar 

  21. Ramesh, V., Eddy, R., Bruns, G.A., Shin, V.E., Shows, T.B., and Gusella, J.F. (1987).Hum. Genet. 76121–126.

    PubMed  Google Scholar 

  22. Chomczynski, P., and Sacchi, N. (1987).Anal. Biochem. 162156–159.

    PubMed  Google Scholar 

  23. Grimaldi, J.C., Torres, R., Kozak, C.A., Chang, R., Clark, E.A., Howard, M., and Cockayne, D.A. (1992).J. Immunol. 1493921–3926.

    PubMed  Google Scholar 

  24. Huebner, K., Isobe, M., Chao, M., Bothwell, M., Ross, A.H., Finan, J., Hoxie, J.A., Seghal, A., Randy Buck, C., Lanahan, A., Nowell, P.C., Koprowski, H., and Croce, C.M. (1986).Proc. Natl. Acad. Sci. U.S.A. 831403–1407.

    PubMed  Google Scholar 

  25. Baker, E., Chen, L.Z., Smith, C.A., Callen, D.F., Goodwin, R., and Sutherland, G.R. (1991).Cytogenet. Cell Genet. 57117–118.

    PubMed  Google Scholar 

  26. Inazawa, J., Itoh, N., Abe, T., and Nagata, S. (1992).Genomics 14821–822.

    PubMed  Google Scholar 

  27. Grezschik, K.H., and Skolnick, M.H. (1991).Cytogenet. Cell Genet. 58785–799.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunology, Children's Hospital, 02115, Boston, Massachusetts

    Narayanaswamy Ramesh & Raif Geha

  2. Laboratory of Neurogenetics, Massachusetts General Hospital, 02115, Boston, Massachusetts

    Vijaya Ramesh & James F. Gusella

  3. the Department of Pediatrics, Harvard Medical School, 02115, Boston, Massachusetts

    Narayanaswamy Ramesh & Raif Geha

  4. the Department of Neurology, Harvard Medical School, 02115, Boston, Massachusetts

    Vijaya Ramesh & James F. Gusella

Authors
  1. Narayanaswamy Ramesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vijaya Ramesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. James F. Gusella
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Raif Geha
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ramesh, N., Ramesh, V., Gusella, J.F. et al. Chromosomal localization of the gene for human B-cell antigen CD40. Somat Cell Mol Genet 19, 295–298 (1993). https://doi.org/10.1007/BF01233077

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01233077

Keywords

Search

Navigation