Summary
HbA1c is the product of a reaction between glucose and the N-terminal valine of adult haemoglobin (HbA). The levels of HbA1c are increased in diabetic patients, and reflect their metabolic control. Thus, measurements of HbA1c have proved to be useful in the follow up and treatment of diabetic patients. HbA1c may prove to be valuable for assessing the relationship between diabetic control and long-term complications, as well as in studying the potential glycosylation of proteins in various organs which may occur in the diabetic state.
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Gonen, B., Rubenstein, A.H. Haemoglobin A1 and diabetes mellitus. Diabetologia 15, 1–8 (1978). https://doi.org/10.1007/BF01219319
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DOI: https://doi.org/10.1007/BF01219319