Skip to main content
SpringerLink
Log in

Signal Transduction and Mechanisms of Cell Death

Sixth Colloquium on Cellular Signal Transduction, 17 January 1997, Heidelberg, Germany

  • Meeting Report
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitrochondrial function. Neuron 15: 961–973

    PubMed  Google Scholar 

  • Bleuel K, Figueroa R, Härle C, Popp S, Vormwald-Dogan V, Boukamp P (1997) Mini review: multistep process of ultraviolet-induced nonmelanoma skin carcinogenesis. Radiation Oncol Invest (in press)

  • Bonfoco E, Leist M, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1996) Cytoskeletal breakdown and apoptosis elicited by NO-donors in cerebellar granule cells require NMDA-receptor activation. J Neurochem 67: 2484–2493

    PubMed  Google Scholar 

  • Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sikorska M, Walker R, Schulte-Hermann R (1996) Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 17: 1595–1607

    PubMed  Google Scholar 

  • Cuthbert AP, Trott DA, Ekong RM, Jazzard S, England NL, Themis M, Todd CM, Newbold RF (1995) Construction and characterisation of a highly stable human: rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies. Cytogenet Cell Genet 71: 68–76

    PubMed  Google Scholar 

  • Daum G, Eisenmann-Tappe I, Fries HW, Troppmair J, Rapp UR (1994) Ins and outs of Raf kinases. Trends Biochem Sci 19: 474–480

    PubMed  Google Scholar 

  • England NL, Cuthbert AP, Trott DA, Jezzard S, Nobori T, Carson DA, Newbold RF (1996) Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (pl6INK4A). Carcinogenesis 17: 1567–1575

    PubMed  Google Scholar 

  • Friesen C, Herr I, Krammer PH, Debatin K-M (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat Med 2: 574–577

    PubMed  Google Scholar 

  • Gack S, Vallon R, Schaper J, Ruther U, Angel P (1994) Phenotypic alterations infos-transgenic mice correlate with changes in FOS/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem 269: 10363–10369

    PubMed  Google Scholar 

  • Gack S, Vallon R, Schmidt J, Grigoriadis A, Tuckermann J, Schenkel J, Weiher H, Wagner EF, Angel P (1995) Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ 6: 759–767

    PubMed  Google Scholar 

  • Galle PR, Hofmann WJ, Walczak H, Schaller H, Otto G, Stremmel W, Krammer PH, Runkel L (1995) Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 182: 1223–1230

    PubMed  Google Scholar 

  • Gandarillas A, Watt FM (1995) Changes in expression of members of thefos andjun families andmyc network during terminal differentiation of human keratinocytes. Oncogene 11: 1403–1407

    PubMed  Google Scholar 

  • Grasl-Kraupp B, Ruttkay-Nedecky B, Müllauer L, Taper H, Huber W, Bursch W, Schulte-Hermann R (1997) Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression. Hepatology 25: 906–912

    PubMed  Google Scholar 

  • Härle-Bachor C, Boukamp P (1996) Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci USA 93: 6476–6481

    PubMed  Google Scholar 

  • Jones PH, Harper S, Watt FM (1995) Stem cell patterning and fate in human epidermis. Cell 80: 83–93

    PubMed  Google Scholar 

  • Leist M, Single B, Castoldi AF, Kühnle S, Nicotera P (1997a) Intracellular ATP concentration: a switch deciding between apoptosis and necrosis. J Exp Med 185: 1481–1486

    PubMed  Google Scholar 

  • Leist M, Fava E, Montecucco C, Nicotera P (1997b) Peroxynitrite and NO-donors induce neuronal apoptosis by eliciting autocrine excitotoxicity. Eur J Neurosci 9: 1488–1498

    PubMed  Google Scholar 

  • Los M, van de Craen M, Penning CL, Schenk H, Westendorp M, Baeuerle PA, Dröge W, Krammer PH, Fiers W, Schulze-Osthoff K (1995) Requirement of an ICE/Ced-3 protease for Fas/APO-1-mediated apoptosis. Nature 371: 81–83

    Google Scholar 

  • Merritt AJ, Potten CS, Watson AJM, Loh DY, Nakayama K, Nakayama K, Hickman JA (1995) differential expression of Bcl-2 in intestinal epithelia: correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J Cell Sci 108: 2261–2271

    PubMed  Google Scholar 

  • Merritt AJ, Allen TD, Potten CS, Hickman JA (1997) Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after γ-irradiation. Oncogene 14: 2759–2766

    PubMed  Google Scholar 

  • Müller M, Strand S, Hug H, Heinemann E-V, Walczak H, Hofmann WJ, Stremmel W, Krammer PH, Galle PR (1997) Drug-induced apoptosis in hepatoma cells involves activation of p53 and is mediated by the CD95 (APO-1/Fas) receptor/ligand system. J Clin Invest 99: 403–413

    PubMed  Google Scholar 

  • Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817–827

    PubMed  Google Scholar 

  • Pritchard DM, Watson AJM, Potten CS, Jackman AL, Hickman JA (1997) Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc Natl Acad Sci USA 94: 1795–1799

    PubMed  Google Scholar 

  • Schreiber M, Baumann B, Cotten M, Angel P, Wagner EG (1995) Fos is an essential component of the mammalian UV response. EMBO J 14: 5338–5349

    PubMed  Google Scholar 

  • Schulte-Hermann R, Bursch W, Grasl-Kraupp B (1995) Active cell death (apoptosis) in liver biology and disease. Prog Liver Dis 13: 1–35

    PubMed  Google Scholar 

  • Schulze-Osthoff K, Bauer M, Vogt M, Los M (1996) Involvement of ICE-related and other proteases in Fas-mediated apoptosis. Cell Death Differ 3: 177–184

    Google Scholar 

  • Strand S, Hofmann WJ, Hug H, Müller M, Otto G, Strand D, Stremmel W, Krammer PH, Galle PR (1996) Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand expressing tumor cells —a mechanism of immune evasion? Nat Med 2: 1361–1366

    PubMed  Google Scholar 

  • Wang HG, Takayama S, Rapp UR, Reed JC (1996a) Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci USA 93: 7063–7068

    PubMed  Google Scholar 

  • Wang HG, Rapp UR, Reed JC (1996b) Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87: 1–20

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Program Tumor Cell Regulation, Deutsches Krebsforschungszentrum, P.O. Box 101949, D-69009, Heidelberg, Germany

    F. Marks & P. Boukamp

Authors
  1. F. Marks
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Boukamp
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The next colloquium on cellular signal transduction (Signal transduction and transport across cellular membranes) will be held at the Deutsches Krebsforschungszentrum on 16 January 1988

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marks, F., Boukamp, P. Signal Transduction and Mechanisms of Cell Death. J Cancer Res Clin Oncol 123, 522–526 (1997). https://doi.org/10.1007/BF01192208

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01192208

Keywords

Search

Navigation