Abstract
Fecal chymotrypsin assays were done on 34 patients with alcoholic liver disease. Only one such patient had low fecal activity. Correlation of fecal chymotrypsin with fat malabsorption and duodenal drainage tests was undertaken. Although fat malabsorption was frequently encountered (13 of 34), the low incidence of abnormal fecal chymotrypsin suggests that severe pancreatic exocrine insufficiency is an unusual occurrence in this population. Six patients had pancreozymin-secretin tests and Lundh test meals and one showed abnormal results, but fecal chymotrypsin assays were uniformly normal in this small subgroup.
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References
Jover A, Gordon RS Jr: Procedure for quantitative analysis of feces with special reference to fecal fatty acids. J Lab Clin Med 59:878–884, 1962
Moeller DD, Dunn GD, Klotz AP: Comparison of the pancreozymin-secretin test and the Lundh test meal, Am J Dig Dis 17:799–805, 1972
van de Kamer JH, ten Bokkel Huinink H, Weyers HA: Rapid method for determination of fat in feces. J Biol Chem 177:347–355, 1949
Greene LK, Rigbi M, Fackre DS: Trypsin inhibitor from bovine pancreatic juice. J Biol Chem 241:5610–5618, 1966
Moeller DD, Dunn GD, Klotz AP: Diagnosis of pancreatic exocrine insufficiency by fecal chymotrypsin activity. Am J Dig Dis 18:792–796, 1973
International Union of Biochemistry: Commission on Enzymes. Amsterdam, Elsevier Press Inc., 1965, p 10
Losowsky MS, Walker BE: Liver disease and malabsorption. Gastroenterology 56:589–600, 1969
Van Goidsenhoven GE, Henke WJ, Vacca JB, Knight WA Jr: Pancreatic function in cirrhosis of the liver. Am J Dig Dis 8:160–173, 1963
Sun DCH, Albacete RA, Chen JK: Malabsorption studies in cirrhosis of the liver. Arch Intern Med 119:567–572, 1967
Gross JB, Comfort MW, Wollaeger EE, Power MH: External pancreatic function in primary parencymatous hepatic disease as measured by analysis of duodenal contents before and after stimulation with secretin. Gastroenterology 16:151–161, 1950
Worning HS, Mullertz S, Thaysen EH, Bang HO: pH and concentration of pancreatic enzymes in aspirates from the human duodenum during digestion of a standard meal in patients with biliary or hepatic disorders. Scand J Gastroenterol 2:150–156, 1967
Moeller DD, Dunn GD, Klotz AP: Pancreatic function in malabsorbing alcoholic cirrhotics. Am J Dig Dis 19:779–784, 1974
Smith JS, Ediss I, Mullinger MA, Bogoch A: Fecal chymotrypsin and trypsin determinations. Can Med Assoc J 104:691–697, 1971
Haverback BJ, Dyce, BJ, Gutentab PJ, Montgomery DW: Measurement of trypsin and chymotrypsin in stool: a diagnostic test for pancreatic exocrine insufficiency. Gastroenterology 34:588–597, 1963
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Moeller, D.D., Dunn, G.D. & Klotz, A.P. Fecal chymotrypsin in alcoholic liver disease. Digest Dis Sci 19, 1138–1142 (1974). https://doi.org/10.1007/BF01076149
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DOI: https://doi.org/10.1007/BF01076149