Skip to main content
SpringerLink
Log in

Effects of cigarette smoking on bicarbonate and volume of duodenal contents

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

The effect of smoking on bicarbonate and volume of duodenal juice was studied. It was found that in the basal condition smoking produced significant decreases in bicarbonate content and volume of duodenal samples. On the contrary, during pancreatic stimulation with secretin at approximately 50% of maximal secretion, smoking resulted in significant increases in bicarbonate output and volume. Decrease in buffering power of duodenal juice in the basal condition can, at least partially, explain the causative relation of smoking and peptic ulcer disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Doll R, Jones FA, Pygott F: Effect of smoking on the production and maintenance of gastric and doudenal ulcers. Lancet 1:657–662, 1958

    Google Scholar 

  2. Monson RR: Cigarette smoking and body form in peptic ulcer. Gastroenterology 58:337–344, 1970

    Google Scholar 

  3. Debas HT, Cohen MM, Holubitsky IB, Harrison RC: Effect of cigarette smoking on human gastric secretory response. Gut 12:93–96, 1971

    Google Scholar 

  4. Cooper P, Knight GB: Effect of cigarette smoking on gastric secretions of patients with duodenal ulcer. N Engl J Med 255:17–21, 1956

    Google Scholar 

  5. Konturek SJ, Solomon TE, McCreight WG, Johnson LR, Jacobson ED: Effect of nicotine on gastrointestinal secretions. Gastroenterology 60:1098–1105, 1971

    Google Scholar 

  6. Konturek SJ, Biernat J, Radecki T: Wplyw palenia tytoniu na wydzielanie soladkowe i trzustkowe u czlowieka. Pol Arch Med Wewn 48:383–388, 1972

    Google Scholar 

  7. Bynum TE, Solomon TE, Johnson LR, Jacobson ED: Inhibition of pancreatic secretion in man by cigarette smoking. Gut 13:361–365, 1972

    Google Scholar 

  8. Aviado DM: Ganglionic stimulants and blocking drugs, Drills' Pharmacology in Medicine. Edited by J. R. DiPalma. New York, The Blakiston Division McGraw-Hill Book Co, 1965

    Google Scholar 

  9. Moreland HJ, Johnson LR: Effect of vagotomy and pyloroplasty on pancreatic secretion stimulated by endogenous and exogenous secretin. Gastroenterology 60:425–431, 1971

    Google Scholar 

  10. Konturek SJ, Popiela T, Thor P: Effect of vagotomy and pyloroplasty on pancreatic dose response curves to secretin in man. Am J Dig Dis 16:1087–1090, 1971

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Internal Medicine, Academy of Medicine, ul. Pasteura 4, Wroclaw, Poland

    Wieslaw J. Bochenek MD & Ryszard Koronczewski MD

Authors
  1. Wieslaw J. Bochenek MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ryszard Koronczewski MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by Ayerst Laboratories, New York.

Boots Secretin was kindly donated by Dr. K. Cartwright of Boots Pure Drug Co. Ltd., Nottingham, England.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bochenek, W.J., Koronczewski, R. Effects of cigarette smoking on bicarbonate and volume of duodenal contents. Digest Dis Sci 18, 729–733 (1973). https://doi.org/10.1007/BF01070841

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01070841

Keywords

Search

Navigation