Abstract
The effect of smoking on bicarbonate and volume of duodenal juice was studied. It was found that in the basal condition smoking produced significant decreases in bicarbonate content and volume of duodenal samples. On the contrary, during pancreatic stimulation with secretin at approximately 50% of maximal secretion, smoking resulted in significant increases in bicarbonate output and volume. Decrease in buffering power of duodenal juice in the basal condition can, at least partially, explain the causative relation of smoking and peptic ulcer disease.
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Supported in part by Ayerst Laboratories, New York.
Boots Secretin was kindly donated by Dr. K. Cartwright of Boots Pure Drug Co. Ltd., Nottingham, England.
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Bochenek, W.J., Koronczewski, R. Effects of cigarette smoking on bicarbonate and volume of duodenal contents. Digest Dis Sci 18, 729–733 (1973). https://doi.org/10.1007/BF01070841
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DOI: https://doi.org/10.1007/BF01070841