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Phenobarbital treatments lower DDT body burden in rhesus monkeys

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Abstract

Decreased DDT, DDD, DDE in blood and DDA in urine followed phenobarbital treatments (10 mg/kg/day, 11 days, intramuscular (im)) in three male rhesus monkeys (Macaca mulatta). Animals were fed DDT diets containing up to 500 ppm DDT during a 3-year period. Induction of liver monooxygenases was confirmed by reducedin vivo antipyrine plasma half-life and increasedin vitro oxidation rates of dihydroisodrin,p- nitroanisole and benz(α)pyrene by homogenates of liver obtained from closed needle biopsy. Chlorohydrocarbon blood levels significantly decreased during the induction period (days 1–11). Concentrations on day 28 were at or below pre-DDT exposure levels. Urine DDA gradually decreased in all monkeys from days 16 to 28.

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  1. Charles R. Clark

    Present address: Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, NM 87115, Albuquerque

Authors and Affiliations

  1. Department of Environmental Toxicology, University of California, 95616, Davis, California

    Paul W. Ferguson, Charles R. Clark, Shirley J. Gee &  Robert I. Krieger

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  1. Paul W. Ferguson
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  3. Shirley J. Gee
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  4. Robert I. Krieger
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Ferguson, P.W., Clark, C.R., Gee, S.J. et al. Phenobarbital treatments lower DDT body burden in rhesus monkeys. Arch. Environ. Contam. Toxicol. 10, 263–270 (1981). https://doi.org/10.1007/BF01055627

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  • DOI: https://doi.org/10.1007/BF01055627

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