Abstract
Simultaneous or separate coagulation of thelocus coeruleus (LC) and the pontine raphe nucleus (PRN) results in a significant increase of irregular-type background activity in the cerebellar fastigial nucleus neurons. There are also considerable changes in the dynamics of impulse sequences, in particular, the number of neurons with random interpulse intervals markedly increases. Destruction of theLC and/or PRN is followed by a marked drop in the mean frequency of discharges in the neurons of the fastigial nucleus.
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References
E. Dietrichs, “Cerebellar cortical and nuclear afferents from the felinelocus coeruleus complex,”Neuroscience,27, No. 1, 77–91 (1988).
V. Chan-Palay, “Fine structure of labelled axons in the cerebellar cortex and nuclei of rodents and primates after intraventricular infusion with tritiated serotonin,”Anat. Embryol.,148, No. 2, 235–265 (1975).
V. Chan-Palay, “Serotonin afferents from raphe nuclei to the cerebellum in mammals. Afferent and intrinsic organization of laminated structures in the brain,”Exp. Brain Res., Suppl. 1, 20–25 (1976).
V. Chan-Palay,Cerebellar Dentate Nucleus, Springer-Verlag, Berlin (1971).
M. V. Khanbabyan, R. Sh. Sarkisyan, and K. A. Manasyan, “Effects oflocus coeruleus and raphe nuclei stimulation on the activity of the cerebellum intermediate nucleus neurons,”Zh. Vissh. Nerv. Deyat.,34, No. 1, 166–168 (1984).
M. V. Khanbabyan and R. Sh. Sarkisyan, “Electrophysiological study of thelocus coeruleus projections into the cerebellum central nuclei,”Neirofiziologiya,21, No. 1, 39–44 (1989).
M. V. Khanbabyan, R. Sh. Sarkisyan, and K. A. Manasyan, “Effect of raphe nucleus stimulation on electrical activity of the cerebellum nuclei,”Fiziol. Zh. SSSR,75, No. 10, 1368–1373 (1989).
R. Sh. Sarkisyan, “Electrophysiological analysis of thelocus coeruleus and pontine raphe nucleus projections into the cerebellum central nuclei,”Abstr. of Cand. Thesis, Biol. Sci. [in Russian], Yerevan (1989).
A. S. Amatuni, R. Sh. Sarkisyan, É. A. Korkotyan, and A. K. Melikyan, “Background impulse activity of the rat cerebellum fastigial nucleus neurons,”Neirofiziologiya,23, No. 4, 441–450 (1991).
R. Sh. Sarkisyan, É. A. Korkotyan, and A. K. Melikyan, “Background impulse activity of the rat cerebellum fastigial nucleus neurons,”Neirofiziologiya,22, No. 5, 702–705 (1990).
F. Abad-Allegria, “Esterotaxic Troncoencefalica,”Trab. Inst. Cajal Invest. Biol.,63, No. 1, 193–224 (1971).
L. N. Bol'shev and N. V. Smirnov,Tables of Mathematical Statistics [in Russian], Nauka, Moscow (1983).
Y. R. Siggins, B. S. Hoffer, A. P. Oliver, and F. E. Bloom, “Activation of a central noradrenergic projection to cerebellum,”Nature,233, 482–483 (1971).
J. L. Barker, “Supraoptic neurosecretory cells: adrenergic and cholinergic sensitivity,”Science,171, 208–210 (1971).
B. J. Hoffer, Y. R. Siggins, and F. R. Bloom, “Response of single cerebellar Purkinje cells to microelectrophoresis of norepinephrine (NE) and serotonin,”Fed. Proc.,28, 443–451 (1969).
J. A. Nathanson, R. Freedman, and B. J. Hoffer, “Lanthanum inhibits brain adenylate cyclase and blocks noradrenergic depression of Purkinje cell discharge independent of calcium,”Nature,261, 230–232 (1971).
F. E. Bloo, B. J. Hoffer, G. S. Siggins, et al., “Effects of serotonin on central neurons: microiontophoretic administration,”Fed. Proc.,31, No. 1, 97–106 (1972).
J. C. Strahlendorf, H. K. Strahlendorf, and C. D. Barnes, “Modulation of cerebellar neuronal activity by raphe stimulation,”Brain Res.,169, 565–569 (1979).
J. C. Strahlendorf, H. K. Strahlendorf, and M. Lee, “Enhancement of cerebellar Purkinje cell complex discharge activity by microiontophoretic serotonin,”Exp. Brain Res.,61, 614–624 (1986).
M. Weiss and J. Pellet, “Raphe-cerebellum interaction. II. Effect of midbrain raphe stimulation and harmaline administration on single unit activity of cerebellar cortical cells in the rat,”Exp. Brain Res.,48, 171–176 (1982).
R. Gardette, M. Krupa, and F. Crepel, “Effects of serotonin on the spontaneous activity and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons of the ratin vitro,”Neurosci. Lett., Supply.26, 232 (1986).
R. Gardette, M. Krupa, and F. Crepel, “Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices,”Neurosci. Lett.,23, No. 2, 491–500 (1987).
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Neirofiziologiya/Neurophysiology, Vol. 26, No. 6, pp. 437–442, November–December, 1994.
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Sarkisyan, R.S., Khanbabyan, M.V. & Mushegyan, G.K. Effects of coagulation of thelocus coeruleus and pontine raphe nuclei on the background activity recorded from the rat cerebellar fastigial nucleus neurons. Neurophysiology 26, 359–364 (1994). https://doi.org/10.1007/BF01053579
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DOI: https://doi.org/10.1007/BF01053579