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Computer-linked HPLC system for feedback control of fermentation substrates

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Summary

A data acquisition/control microcomputer system was interfaced to a commercial HPLC data transmission module. Control of substrate (ethanol) levels for four 7.5 L fermenters containing 100 g/L wet weight of the yeastCandida norvegensis was accomplished by employing intermittent, automated HPLC monitoring and a BASIC-encoded proportional integral policy for controlling substrate feed rates. Ethanol levels were maintained at 0.25, 0.50, 0.75 and 1.00% w/v.

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References

  • K. Dairaku, et. al. (1983). J. Ferment. Tehnol. 61, 189.

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  • R. C. Dinwoodie and D. W. Mehnert. (1985). Biotechnol. Bioeng. 27, 1060.

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  • T. Yamane and S. Shimizu. (1984). in Advances in Biochemical Engineering/ Biotechnology. 30, 147–194.

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Authors and Affiliations

  1. Kraft, Inc. Research and Development, 801 Waukegan Rd., 60025, Glenview, IL

    Jeremy J. Mathers, Robert C. Dinwoodie, Martin Talarovich & David W. Mehnert

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  1. Jeremy J. Mathers
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  2. Robert C. Dinwoodie
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  3. Martin Talarovich
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  4. David W. Mehnert
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Mathers, J.J., Dinwoodie, R.C., Talarovich, M. et al. Computer-linked HPLC system for feedback control of fermentation substrates. Biotechnol Lett 8, 311–314 (1986). https://doi.org/10.1007/BF01040855

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  • DOI: https://doi.org/10.1007/BF01040855

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