Summary
The regiospecific biotransformation of (±) 5-acetoxy-7-fluoronorbornan-2-one into the equivalent bridgehead lactone of use as a source of substituted cyclopentane synthons containing four successive chiral centres has been demonstrated using washed-cell suspensions of cyclohexanol-grownAcinetobacter sp NCIB 9871. Conditions to optimise production of such 2-oxabicyclooctanones (substrate concentration<25mM, pH 7.35, 30°C) have been characterised.
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Levitt, M., Sandey, H. & Willetts, A. Regiospecific biotransformation of substituted norbornanones by microorganisms. Biotechnol Lett 12, 197–200 (1990). https://doi.org/10.1007/BF01026798
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DOI: https://doi.org/10.1007/BF01026798