Zusammenfassung
Die ErythropoetinaktivitÄt wurde im Serum und Urin von Patienten mit aplastische AnÄmie gemessen. Die Erythropoetinspiegel waren in den Seren aller untersuchten Patienten und im Urin bei 17 von 23 Personen erhöht. Es bestand keine Korrelation zwischen HÄmoglobinwerten und Höhe der Erythropoetinspiegel. Serum-Erythropoetin war bei Patienten mit aplastischer AnÄmie deutlicher erhöht als bei Patienten mit sideropenischer AnÄmie gleichen Schweregrades. Möglicherweise beruht die deutlichere Zunahme des Erythropoetins bei den Patienten mit aplastischer AnÄmie und damit einem hypozellulÄren Knochenmark auf einem verminderten Verbrauch des Hormons, weil im Stammzellkompartiment weniger auf Erythropoetin ansprechende Zellen vorhanden sind.
Summary
The level of erythropoietin (Ep) was measured in sera and urine from aplastic anemia patients. Increased levels of Ep were demonstrated in sera from all 25 patients studied. An elevated level of Ep was found in the urine of 17 of 23 patients in whom the urine was tested. No correlation between blood hemoglobin and Ep level was observed. A higher serum Ep level was noted in patients with aplastic anemia than in patients with sideropenic anemia of the same severity. To explain the discrepancy, diminished Ep consumption in bone marrow of aplastic anemia patients is discussed.
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This work was supported by a grant form the Medical Scientific Fund of Serbia
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Pavlovic-Kentera, V., Milenkovic, P., Ruvidic, R. et al. Erythropoietin in aplastic anemia. Blut 39, 345–350 (1979). https://doi.org/10.1007/BF01014197
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DOI: https://doi.org/10.1007/BF01014197