Skip to main content
SpringerLink
Log in

Biological significance of prostaglandins with special reference to their effects on metabolism

  • Published:
Naunyn-Schmiedebergs Archiv für Pharmakologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Ahn, C. S., Rosenberg, I. N.: Iodine metabolism in thyroid slices: Effects of TSH, dibutyryl cyclic 3′,5′-AMP, NaF and prostaglandin E1. Endocrinology86, 396–405 (1970a).

    Google Scholar 

  • — —: Proteolysis in thyroid slices: Effects of TSH, dibutyryl cyclic 3′,5′-AMP and prostaglandin E1. Endocrinology86, 870–873 (1970b).

    Google Scholar 

  • Armstrong, D. L., Jackanicz, T. M., Keyes, P. L.: Regulation of steroidogenesis in the rabbit ovary. In: The gonads, pp. 3–25, K. W. McKerns, Ed. Amsterdam: North Holland Publishing Co. 1969.

    Google Scholar 

  • Bartels, J., Vogt, W., Willie, G.: Prostaglandin release from and formation in perfused frog intestine. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path.259, 153–154 (1968); [see erratum259, 459 (1968)].

    Google Scholar 

  • Beck, N. P., Field, J. B., Davis, B.: Effect of prostaglandin E1 (PGE1) chlorpropamide (CPM) and vasopressin (VP) on cyclic 3′5′ adenosine monophosphate (CAMP) in renal medulla of rats. Clin. Res.18, 494 (1970).

    Google Scholar 

  • Bedwani, J. R., Horton, E. W.: The effects of prostaglandins E1 and E2 on ovarian steroidogenesis. Life Sci.7, Part I, 389–393 (1968).

    Google Scholar 

  • Bergström, S., Carlson, L. A., Weeks, J. R.: The prostaglandins: A family of biologically active lipids. Pharmacol. Rev.20, 1–48 (1968).

    Google Scholar 

  • Bizzi, A., Codegoni, A. M., Lietti, A., Garattini, S.: Different responses of white and brown adipose tissue to drugs affecting lipolysis. Biochem. Pharmacol.17, 2407–2412 (1968).

    Google Scholar 

  • Blecher, M., Merlino, N. S., Ro'Ane, J. T., Flynn, P. D.: Independence of the effects of epinephrine, glucagon, and adrenocorticotropin on glucose utilization from those on lipolysis in isolated rat adipose cells. J. biol. Chem.244, 3423–3429 (1969).

    Google Scholar 

  • Böhle, E., Döbert, R., Ammon, J., Beyer, J.: Untersuchungen über die Wirkungen von Prostaglandin E1 (PGE1) auf den Fettstoffwechsel. In: Fette in der Medizin, Series 7, S. 20–25. N. Henning u. G. Berg, Ed. München: Pallas 1966.

    Google Scholar 

  • —, Rettberg, H., Ditschuneit, H. H., Döbert, R., Ditschuneit, H.: Tierexperimentelle Untersuchungen über die Beeinflussung des Fett- und Kohlenhydratstoff-wechsels durch Prostaglandin E1. Verh. dtsch. Ges. inn. Med.73, 797–801 (1967).

    Google Scholar 

  • Braun, T., BÄr, H.-P., Soifer, D., Hechter, O. M.: Effect of insulin (I), prostaglandin E1 (PGE1) and ouabain (0) on adenyl cylase of rat fat cell plasma membranes. Abstracts, 51st Meeting Endocr. Soc., New York, p. 99 (1969).

  • Bressler, R., Vargas-Cordon, M., Lebovitz, H. E.: Tranylcypromine: a potent insulin secretagogue and hypoglycemic agent. Diabetes17, 617–624 (1968).

    Google Scholar 

  • Burke, G.: On the role of adenyl cyclase activation and endocytosis in thyroid slice metabolism. Endocrinology86, 353–359 (1970a).

    Google Scholar 

  • —: Effects of iodide on thyroid stimulation. J. clin. Endocr.30, 76–84 (1970b).

    Google Scholar 

  • —: Effects of prostaglandins on basal and stimulated thyroid function. Amer. J. Physiol.218, 1445–1452 (1970c).

    Google Scholar 

  • Butcher, R. W.: The second messenger concept and lipid metabolism. Naunyn-Schmiedebergs Arch Pharmak.269, 358–372 (1971).

    Google Scholar 

  • —, Baird, C. E.: Effects of prostaglandins on adenosine 3′,5′-monophosphate levels in fat and other tissues. J. biol. Chem.243, 1713–1717 (1968).

    Google Scholar 

  • Carlson, L. A., Hallberg, D.: Basal lipolysis and effects of norepinephrine and prostaglandin E1 on lipolysis in human subcutaneous and omental adipose tissue. J. Lab. clin. Med.71, 368–377 (1968).

    Google Scholar 

  • Chase, L. R., Aurbach, G. D.: The effect of parathyroid hormone on the concentration of adenosine 3′,5′-monophosphate in skeletal tissuein vitro. J. biol. Chem.245, 1520–1526 (1970).

    Google Scholar 

  • Coceani, F., Pace-Asciak, C., Volta, F., Wolfe, L. S.: Effect of nerve stimulation on prostaglandin formation and release from the rat stomach. Amer. J. Physiol.213, 1056–1064 (1967).

    Google Scholar 

  • Cole, B., Robinson, G. A., Hartmann, R. C.: Effects of prostaglandin E1 and theophylline on aggregation and cyclic AMP levels of human blood platelets. Fed. Proc.29, 316 (1970).

    Google Scholar 

  • Daniels, E. G., Pike, J. E.: Isolation of prostaglandins. In: Prostaglandin Symposium of the Worcester Foundation for Exp. Biol., pp. 379–387. P. W. Ramwell, and J. E. Shaw, Ed. New York: Interscience 1968.

    Google Scholar 

  • Davis, B., Zor, U., Kaneko, T., Mintz, D. H., Field, J. B.: Effects of parathyroid extract (PTE), arginine vasopressin (AVP) and prostaglandin E1 (PGE1) on urinary and renal tissue cyclic 3′5′-adenosine monophosphate (CAMP). Clin. Res.17, 458 (1969).

    Google Scholar 

  • Dekker, A., Field, J. B.: Correlation of effects of thyrotropin, prostaglandins and ions on glucose oxidation, cyclic-AMP, and colloid droplet formation in dog thyroid slices. Metabolism19, 453–464 (1970).

    Google Scholar 

  • De Wied, D., Witter, A., Versteeg, D. H. G., Mulder, A. H.: Release of ACTH by substances of central nervous system origin. Endocrinology85, 561–569 (1969).

    Google Scholar 

  • Efendić, S.: Influence of prostaglandin E1 on lipolysis induced by nor-adrenaline, isopropylnoradrenaline, theophylline, and dibutyryl cAMP in human omental adipose tissue in vitro. Acta med. scand.187, 503–507 (1970).

    Google Scholar 

  • Fain, J. N., Loken, S. C.: Response of trypsin-treated brown and white fat cells to hormones. J. biol. Chem.244, 3500–3506 (1969).

    Google Scholar 

  • Flack, J. D., Jessup, R., Ramwell, P. W.: Prostaglandin stimulation of rat corticosteroidgenesis. Science163, 691–692 (1969) [Errata: increase all prostaglandin concentrations 10 fold, personal communication].

    Google Scholar 

  • Fredholm, B. B., Rosell, S.: Metabolic effects of prostaglandin E1 in canine adipose tissue in situ. Acta physiol. scand.74, 6A (1969).

    Google Scholar 

  • Fried, J., Santhanakrishnan, T. S., Himizu, J., Lin, C. H., Ford, S. H., Rubin, B., Grigas, E. O.: Prostaglandin antagonists: Synthesis and smooth muscle activity. Nature (Lond.)223, 208–210 (1969).

    Google Scholar 

  • Froesch, E. R.: The physiology and pharmacology of adipose tissue lipolysis: Its inhibition and implications for the treatment of diabetes. Diabetologia3, 475–487 (1967).

    Google Scholar 

  • Grantham, J. J., Orloff, J.: Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3′,5′-monophosphate, and theophylline. J. clin. Invest.47, 1154–1161 (1968).

    Google Scholar 

  • Hasselblatt, A.: Interrelations between lipid and carbohydrate metabolism. Naunyn-Schmiedebergs Arch. Pharmak.269, 331–346 (1971).

    Google Scholar 

  • Hepp, D., Menahan, L. A., Wieland, O.: On the role of 3′,5′-cyclic AMP phosphodiesterase in insulin action on rat liver and adipose tissue. Hormone Metab. Res.1, 93–94 (1969).

    Google Scholar 

  • Horton, E. W.: Hypotheses on physiological roles of prostaglandins. Physiol. Rev.49, 122–161 (1969).

    Google Scholar 

  • Jouvenaz, G. H., Nugteren, D. H., Beerthuis, R. K., Van Dorp, D. A.: A sensitive method for the determination of prostaglandins by gas chromatography with electron-capture detection. Biochim. biophys. Acta (Amst.)202, 231–234 (1970).

    Google Scholar 

  • Kaneko, T., Zor, Z., Field, J. B.: Thyroid-stimulating hormone and prostaglandin E1 stimulation of cyclic 3′,5′-adenosine monophosphate in thyroid slices. Science163, 1062–1063 (1969).

    Google Scholar 

  • Klein, D. C., Raisz, L. G.: Prostaglandins: Stimulation of bone resorption in tissue culture. Endocrinology86, 1436–1440 (1970).

    Google Scholar 

  • Kuehl, F. A., Jr., Humes, J. L., Tarnoff, J., Cirillo, V. J., Ham, E. A.: Prostaglandin receptor site: Evidence for an essential role in the action of luteinizing hormone. Science169, 883–886 (1970).

    Google Scholar 

  • Lands, W. E. M., Samuelsson, B.: Phospholipid precursors of prostaglandins. Biochim. biophys. Acta (Amst.)164, 426–429 (1968).

    Google Scholar 

  • MacLeod, R. M., Lehmeyer, J. E.: Prostaglandin-mediated release of growth hormone. Clin. Res.18, 366 (1970).

    Google Scholar 

  • Marquis, N. R., Vigdahl, R. L., Tavormina, P. A.: Platelet aggregation. I. Regulation by cyclic AMP and prostaglandin E1. Biochem. biophys. Res. Commun.36, 965–972 (1969).

    Google Scholar 

  • Marsh, J. M.: The stimulatory effect of prostaglandin E2 on adenyl cyclase in the bovine corpus luteum. FEBS Letters7, 283–286 (1970).

    Google Scholar 

  • Maxwell, G. M.: The effect of prostaglandin E1 upon the general and coronary haemodynamics and metabolism of the intact dog. Brit. J. Pharmacol.31, 162–168 (1967).

    Google Scholar 

  • May, B., Helmstaedt, D., Jeuck, K., Böhle, E.: über metabolische Wirkungen verschiedener Prostaglandine im Tierversuch. Verh. dtsch. Ges. inn. Med.75, 806–808 (1969).

    Google Scholar 

  • —, Omonsky, H. G., Böhle, E.: über die blutzuckersteigernde Wirkung von Prostaglandin E1. Z. ges. exp. Med.148, 99–107 (1968).

    Google Scholar 

  • Micheli, H.: Factors modifying the effect of prostaglandin E1 on lipolysis in adipose tissue. In: Drugs affecting lipid metabolism, pp. 75–84. W. L. Holmes, L. A. Carlson, and R. Paoletti, Ed. New York: Plenum Press 1969.

    Google Scholar 

  • Moghissi, K. S., Murray, C. P.: The function of prostaglandins in reproduction. Obstet. gynec. Surv.25, 281–296 (1970).

    Google Scholar 

  • Murad, F., Brewer, H. B., Vaughan, M.: Effect of thyrocalcitonin on adenosine 3′ ∶ 5′-cyclic phosphate formation by rat kidney and bone. Proc. nat. Acad. Sci. (Wash.)65, 446–453 (1970).

    Google Scholar 

  • Onaya, T., Solomon, D. H.: Stimulation by prostaglandin E1 of endocytosis and glucose oxidation in canine thyroid slices. Endocrinology86, 423–426 (1970).

    Google Scholar 

  • Pace-Asciak, C., Morawska, K., Coceani, F., Wolfe, L. S.: The biosynthesis of prostaglandins E2 and F2 α in homogenates of the rat stomach. In: Prostaglandin Symposium of the Worcester Foundation for Exp. Biol., pp. 371–378. P. W. Ramwell and J. E. Shaw. New York: Interscience 1968.

    Google Scholar 

  • Peng, T.-C., Six, K. M., Munson, P. L.: Effect of prostaglandin E1 on the hypothalamo-hypophyseal-adrenal cortical axis of rats. Fed. Proc.28, 437 (1969).

    Google Scholar 

  • Pharriss, B. B., Wyngarden, L. J., Gutknecht, G. D.: Biological interactions between prostaglandins and luteotropins in the rat. In: Gonadotropins 1968, pp. 121–129. E. Rosemberg, Ed. Los Altos: Geron-X 1968.

    Google Scholar 

  • Ramwell, P. W., Shaw, J. E.: Biological significance of the prostaglandins. Recent Progr. Hormone Res.26, 139–187 (1970).

    Google Scholar 

  • Robison, G. A.: Cyclic AMP as a second messenger. J. Reprod. Fertil., suppl.10, 55–74 (1970).

    Google Scholar 

  • —, Arnold, A., Hartmann, R. C.: Divergent effects of epinephrine and prostaglandin E1 on the level of cyclic AMP in human blood platelets. Pharmacol. Res. Commun.1, 325–332 (1969).

    Google Scholar 

  • Rodesch, F., Neve, P., Willems, C., Dumont, J. E.: Stimulation of thyroid metabolism by thyrotropin, cyclic 3′ ∶ 5′-AMP, dibutyryl cyclic 3′ ∶ 5′-AMP and prostaglandin E1. Europ. J. Biochem.8, 26–32 (1969).

    Google Scholar 

  • Samuelsson, B.: Biosynthesis of prostaglandins. Progr. Biochem. Pharmacol.5, 109–128 (1969).

    Google Scholar 

  • Shaw, J. E., Ramwell, P. W.: Release of prostaglandin from rat epididymal fat pad on nervous and hormonal stimulation. J. biol. Chem.243, 1498–1503 (1968).

    Google Scholar 

  • Sobel, B. E., Robison, A. K.: Activation of guinea pig myocardial adenyl cyclase by prostaglandins. Circulation40, suppl. III, 189 (1969).

    Google Scholar 

  • Speroff, L., Ramwell, P. W.: Prostaglandins in reproductive physiology. Amer. J. Obstet. Gynec.107, 1111–1130 (1970a).

    Google Scholar 

  • — —: Prostaglandin stimulation ofin vitro progesterone synthesis. J. clin. Endocr.30, 345–350 (1970b).

    Google Scholar 

  • Stock, K., Aulich, A., Westermann, E.: Studies on the mechanism of antilipolytic action of prostaglandin E1. Life Sci.7, part. I, 113–134 (1968).

    Google Scholar 

  • Sutherland, E. W., Robison, G. A.: The role of cyclic AMP in the control of carbohydrate metabolism. Diabetes18, 797–819 (1969).

    Google Scholar 

  • — —, Butcher, R. W.: Some aspects of the biological role of adenosine 3′,5′-monophosphate (cyclic AMP). Circulation37, 279–306 (1968).

    Google Scholar 

  • Vigdahl, R. L., Marquis, N. R., Tavormina, P. A.: Platelet aggregation. II. Adenyl cyclase, prostaglandin E1, and calcium. Biochem. biophys. Res. Commun.37, 37, 409–415 (1969).

    Google Scholar 

  • Vogt, W.: Release of prostaglandins by venoms and by endogenous mechanisms.In: International Symposium on Drugs of Animal Origin, pp. 29–33. A. Leonardi and J. Walsh, Ed. Milan: Ferro Edizioni 1967.

    Google Scholar 

  • - Bartels, J., Kunze, H., Meyer, U.: A possible physiological role of phospholipase A for the formation and release of prostaglandin. Abstracts, 4th Int. Congre. Pharmacol., p. 378, Basel 1969a.

  • —, Meyer, U., Kunze, H., Lufft, E., Babilli, S.: Entstehung von SRS-C in der durchströmten Meerschweinchenlunge durch Phospholipase A. Identifizierung mit Prostaglandin. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path.262, 124–134 (1969b).

    Google Scholar 

  • Vonkeman, H., Van Dorp, D. A.: The action of prostaglandin synthetase on 2-arachidonyl-lecithin. Biochim. biophys. Acta (Amst.)164, 430–432 (1968).

    Google Scholar 

  • Waitzman, M. B.: Possible new concepts relating prostaglandins to various ocular functions. Surv. Ophthal.14, 301–326 (1970).

    Google Scholar 

  • Weeks, J. R.: The prostaglandins: Biologically active lipids with implications in circulatory physiology. Circulat. Res.24, suppl. I, 123–129 (1969).

    Google Scholar 

  • —: Prostaglandins: The status of their utility in cardiovascular and other diseases. Rush Presbyterian-St. Luke's Hosp. med. Bull.9, 87–92 (1970).

    Google Scholar 

  • —: Pharmacology of prostaglandin F2 α on the uterus and corpus luteum. In Proc. 4th Int. Congr. Pharmacol., Basle 1969, Vol. 4, pp. 49–53. Basle: Schwabe 1970.

    Google Scholar 

  • Westermann, E., Stock, K.: Inhibitors of lipolysis: Potency and mode of action of α- and Β-adrenolytics, methoxamine derivatives, prostaglandin E1 and phenylisopropyl adenosine. In: Horm. metab. Res., suppl. 2, Adipose tissue regulation and metabolic functions, pp. 47–54. B. Jeanrenaud and D. Hepp, Ed. Stuttgart: G. Thieme 1970.

    Google Scholar 

  • Willebrands, A. F., Tasseron, S. J. A.: Effect of hormones on substrate preference in isolated rat heart. Amer. J. Physiol.215, 1089–1095 (1968).

    Google Scholar 

  • Wolfe, S. M., Muenzer, J., Shulman, N. R.: The role of cyclic adenosine-3′,5′mono-phosphate and prostaglandin in platelet aggregation. J. clin. Invest.49, 104A (1970).

    Google Scholar 

  • —, Shulman, N. R.: Adenyl cyclase activity in human platelets. Biochem. biophys. Res. Commun.35, 265–272 (1969).

    Google Scholar 

  • Zieve, P. D., Greenough, W. B.: Adenyl cyclase in human platelets: activity and responsiveness. Biochem. biophys. Res. Commun.35, 462–466 (1969).

    Google Scholar 

  • Zor, U., Bloom, G., Lowe, I. P., Field, J. B.: Effects of theophylline, prostaglandin E1 and adrenergic blocking agents on TSH stimulation of thyroid intermediary metabolism. Endocrinology84, 1082–1088 (1969a).

    Google Scholar 

  • —, Kaneko, T., Lowe, I. P., Bloom, G., Field, J. B.: Effect of thyroid-stimulating hormone and prostaglandins on thyroid adenyl cyclase activation and cyclic adenosine 3′,5′-monophosphate. J. biol. Chem.244, 5189–5195 (1969b).

    Google Scholar 

  • — —, Schneider, H. P. G., McCann, S. M., Lowe, I. P., Bloom, G., Borland, B., Field, J. B.: Stimulation of anterior pituitary adenyl cyclase activity and adenosine 3′,5′-cyclic phosphate by hypothalamic extract and prostaglandin E1. Proc. nat. Acad. Sci. (Wash.)63, 918–925 (1969c).

    Google Scholar 

  • — — — —, Field, J. B.: Further studies of stimulation of anterior pituitary cyclic adenosine 3′,5′-monophosphate formation by hypothalamic extract and prostaglandins. J. biol. Chem.245, 2883–2888 (1970).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Experimental Biology Division, The Upjohn Company, 49001, Kalamazoo, Michigan, USA

    James R. Weeks

Authors
  1. James R. Weeks
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weeks, J.R. Biological significance of prostaglandins with special reference to their effects on metabolism. Naunyn-Schmiedebergs Arch. Pharmak. 269, 347–357 (1971). https://doi.org/10.1007/BF01003049

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01003049

Keywords

Search

Navigation