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Zum Mechanismus der 2-Propanoloxydation

On the mechanism of the oxidation of 2-propanol

Interferenzversuche mit niederen aliphatischen Alkoholen in vivo und an der isoliert perfundierten Rattenleber

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Summary

The elimination of 2-propanol from the blood of rats as well as from the isolated perfused rat liver is inhibited by ethanol and 1-propanol, whereas methanol and tert. butanol have no effect on the elimination of 2-propanol. Vice versa, 2-propanol delays ethanol elimination. 2-propanol has no influence on the elimination of 1-propanol in the concentration range examined. The results show that 2-propanol is metabolized by ADH. The change in the kinetics of the elimination of ethanol caused by 2-propanol and 1-propanol from zero to first and higher orders demonstrates a competition for ADH.

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Auszugsweise vorgetragen auf der Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft 1969.

FrÄulein J. Ahamer und Frau S. Löbel danken wir für sorgfÄltige und gewissenhafte Mitarbeit.

Mit Unterstützung der Deutschen Forschungsgemeinschaft.

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Abshagen, U., Rietbrock, N. Zum Mechanismus der 2-Propanoloxydation. Naunyn-Schmiedebergs Arch. Pharmak. 265, 411–424 (1970). https://doi.org/10.1007/BF00997077

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  • DOI: https://doi.org/10.1007/BF00997077

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