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Eimeria tenella: Anticoccidial action of drugs in birds with surgically closed ceca

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Summary

Surgical ligation of chick ceca was used to study the role of absorption and extraintestinal transport in the action of anticoccidial drugs. The administration of drugs in the feed was started after ligation of one of the paired ceca. Birds were inoculated orally with oocysts ofEimeria tenella before cecal ligation or were given bilateral cecal injections of sporozoites after ligation. Cecal lesions caused by the coccidia were evaluated and compared on day 6 postinoculation.

Lesions in ligated and unligated ceca were reduced by feeding robenidine (33 ppm), arprinocid (70 ppm), zoalene (125 ppm), aklomide (250 ppm), clopidol (125 ppm), nicarbazin (125 ppm), monensin (120 ppm), salinomycin (60 ppm), and lasalocid (75 ppm). The lesions were more severe in the ligated cecum than in the intact cecum, whether in nonmedicated or medicated birds, but the differences were statistically significant only upon treatment with amprolium, aklomide, robenidine, and clopidol. Generally, however, all drugs except amprolium, significantly reduced the lesions in the ligated cecum in comparison with the control, nonmedicated ligated cecum. Therefore, we concluded that the systemic absorption of most anticoccidial drugs contributes significantly to their efficacy against coccidia in the intestinal mucosa.

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References

  • Ball, S.J.: Chemotherapy of caecal coccidiosis in chickens. The activity of nicarbazin. Vet. Rec.71, 86–91 (1959)

    Google Scholar 

  • Bradley, R.E., Radhakrishnan, C.V.: Coccidiosis in chickens: Obligate relationship betweenEimeria tenella and certain species of cecal microflora in the pathogenesis of the disease. Avian Dis.17, 461–476 (1973)

    PubMed  Google Scholar 

  • Duncan, D.B.: Multiple range and multiple F tests. Biometrics11, 1–42 (1955)

    Google Scholar 

  • Hymas, T.A., Stevenson, G.T.: A study of the action of zoalene onEimeria tenella andEimeria necatrix when administered in the diet or in the drinking water. Poult. Sci.39, 1261–1262 (1960)

    Google Scholar 

  • Johnson, J., Reid, W.M.: Anticoccidial drugs: Lesion scoring techniques in battery and floor-pen experiments with chickens. Exp. Parasitol.28, 30–36 (1970)

    PubMed  Google Scholar 

  • Johnson, J., Reid, W.M., Kemp, R.L.: The development ofEimeria tenella in germfree chicks. In: Germfree research, J.B. Heneghan, ed., p. 457–460 New York: Academic Press 1973

    Google Scholar 

  • Joyner, L.P.: The coccidiostatic activity of 3,5-dinitro-ortho-toluamide againstEimeria tenella. Res. Vet. Sci.1, 363–370 (1960)

    Google Scholar 

  • Long, P.L., Millard, B.J.:Eimeria: Effect of meticlorpindol and methyl benzoquate on endogenous stages in the chicken. Exp. Parasitol.23, 331–338 (1968)

    PubMed  Google Scholar 

  • Matsuzawa, T.: Studies on the model of action of beclotiamine onEimeria tenella. Parasitology77, 235–241 (1978)

    PubMed  Google Scholar 

  • McDougald, L.R., Galloway, R.B.:Eimeria tenella: Anticoccidial drug activity in cell cultures. Exp. Parasitol.34, 189–196 (1973)

    PubMed  Google Scholar 

  • McDougald, L.R., Galloway, R.B.: Anticoccidial drugs: Effects on infectivity and survival intracellulary ofEimeria tenella sporozoites. Exp. Parasitol.40, 314–319 (1976)

    PubMed  Google Scholar 

  • McDougald, L.R., Galloway, R.B.:Eimeria tenella: Inhibition of development in cell culture by serum from chickens fed anticoccidial drugs. Z. Parasitenkd.54, 95–100 (1977)

    PubMed  Google Scholar 

  • Roger, E.F., Clark, R.L., Pessolano, A.A., Becher, H.J., Leanza, W.J., Sorett, L.H., Cuckler, C.C., McManus, E., Garzillo, M., Malanga, C., Ott, W.H., Dickinson, A.M., Van Iderstine, A.: Antiparasitic drugs. III. Thiamine reversible coccidiostats. J. Am. Chem. Soc.82 (2), 2974–2975 (1960)

    Google Scholar 

  • Ryley, J.F.: Studies on the mode of action of quinolone and pyridone coccidiostats. J. Parasitol.53, 1151–1160 (1967)

    PubMed  Google Scholar 

  • Ryley, J.F., Wilson, R.F.: Studies on the mode of action of the coccidiostat robenidine. Z. Parasitenkd.37, 85–93 (1971)

    PubMed  Google Scholar 

  • Shumard, R.F., Callender, M.E., Reid, W.M.: Monensin, a new anticoccidial agent. 14th Cong. Mundial de Avicultura. Madrid, Spain, Vol.3, pp. 421–427 1970

    Google Scholar 

  • Visco, R.J., Burns, W.C.:Eimeria tenella in monoflora and diflora chicks. J. Parasitol.58, 576–585 (1972)

    PubMed  Google Scholar 

  • Waletzky, E., Probst, R.: The role of absorption in the activity of anticoccidial agents againstEimeria tenella. J. Parasitol.43, (5) (suppl.) 18 (1957)

    Google Scholar 

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Authors and Affiliations

  1. Department of Poultry Science, University of Georgia, 30602, Athens, Georgia, USA

    T. E. McQuistion & L. R. McDouglad

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  1. T. E. McQuistion
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  2. L. R. McDouglad
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McQuistion, T.E., McDouglad, L.R. Eimeria tenella: Anticoccidial action of drugs in birds with surgically closed ceca. Z. Parasitenkd. 59, 107–113 (1979). https://doi.org/10.1007/BF00927392

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  • DOI: https://doi.org/10.1007/BF00927392

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