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Metabolism of arachidonic acid in rabbit alveolar macrophages

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Abstract

Rabbit alveolar macrophages incorporated radioactive arachidonic acid primarily into phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and triglycerides. When these cells, so labelled, were washed and treated with polystyrene beads, there was a distinct and reproducible decrease in the radioactivity of phosphatidylcholine, phosphatidylethanolamine, and triglyceerides. This decrease was accounted for by the appearance of two major prostaglandins, PGE2 and PGF2a, and uncharacterized hydroxy fatty acids, which may be 12-hydroxy-5,8,10,14-eicosatetraenoic acid, 5-hydroxy-6,8,11, 14-eicosatetraenoic acid, and/or 8-hydroxy-9,11,14-eicosatrienoic acid.

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Authors and Affiliations

  1. Departments of Biochemistry and Medicine, Duke University Medical Center, 27710, Durham, North Carolina

    Saura Sahu & William S. Lynn

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  1. Saura Sahu
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  2. William S. Lynn
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Sahu, S., Lynn, W.S. Metabolism of arachidonic acid in rabbit alveolar macrophages. Inflammation 2, 191–197 (1977). https://doi.org/10.1007/BF00917595

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