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Furosemide dynamics in conscious rabbits: Modulation by arginine vasopressin

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Summary

The aims of this study were to assess the influence of arginine-vasopressin (AVP) on the pharmacodynamics and kinetics of furosemide. To this purpose, the response and the kinetics of furosemide (5 mg/kg i.v.) were studied in two groups of rabbits, one control and one receiving an infusion of AVP (2.5 ng/kg/min). The infusion of AVP generated mean plasma levels of 35 pg/ml, and in these rabbits osmolal clearance was increased, free water clearance was reduced, and renal plasma flow was reduced by 25% (p<0.05). High AVP plasma levels increased the natriuresis (p<0.01) and the urinary excretion of prostaglandin E2 (UPgE2V; p<0.01). The increase in UPgE2V was associated with AVP plasma concentrations (r=0.8248; p<0.001). AVP reduced the increment in natriuresis and diuresis elicited by furosemide from 163±20 to 87±20 µmol/min (p<0.05) and from 1.22±0.11 to 0.83±0.13 ml/min (p<0.05). The infusion of AVP enhanced furosemide metabolic clearance but diminished its renal clearance, resulting in a decrease in the rate of furosemide urinary secretion. It was concluded that high plasma levels of AVP reduce furosemide natriuresis, presumably because of a decrease in furosemide urinary secretion.

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  1. Département de Pharmacologie, Faculté de Médecine, Université de Montréal, Succ. “Centre ville,”, C.P. 6128, H3C 3J7, Montréal, Québec, Canada

    Roberto Babini & Patrick du Souich

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  1. Roberto Babini
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  2. Patrick du Souich
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Babini, R., du Souich, P. Furosemide dynamics in conscious rabbits: Modulation by arginine vasopressin. Cardiovasc Drug Ther 9, 305–310 (1995). https://doi.org/10.1007/BF00878675

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  • DOI: https://doi.org/10.1007/BF00878675

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