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Renal and extrarenal sites of action of diuretics

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Summary

This paper provides (a) a survey of the basic tubule transport mechanisms of sodium and potassium ions along the nephron, (b) a comparison of the overall renal effects of two diuretic agents (torasemide and furosemide), as assessed by renal clearance techniques, (c) an analysis of the tubule sites of action of torasemide evaluated by free-flow micropuncture and microperfusion techniques, and (d) a brief evaluation of some extrarenal transport effects of loop diuretics.

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Authors and Affiliations

  1. Department of Cellular & Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA

    Gerhard Giebisch M.D., Gertruida Klein-Robbenhaar, Johanna Klein-Robbenhaar, Klaus Ratheiser & Robert Unwin

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  1. Gerhard Giebisch M.D.
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  2. Gertruida Klein-Robbenhaar
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  3. Johanna Klein-Robbenhaar
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  4. Klaus Ratheiser
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  5. Robert Unwin
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Giebisch, G., Klein-Robbenhaar, G., Klein-Robbenhaar, J. et al. Renal and extrarenal sites of action of diuretics. Cardiovasc Drug Ther 7 (Suppl 1), 11–21 (1993). https://doi.org/10.1007/BF00877954

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