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Genetic control of polyketide biosynthesis in the genusStreptomyces

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Abstract

The genetic control of polyketide metabolite biosynthesis inStreptomyces sp. producing actinorhodin, daunorubicin, erythromycin, spiramycin, tetracenomycin and tylosin is reviewed. Several examples of positively-acting transcriptional regulators of polyketide metabolism are known, including some two-component sensor kinase-response regulator systems. Translational and posttranslational control mechanisms are only briefly mentioned since very little is known about either of these processes. Examples of how enzyme levels and substrate supply affect polyketide metabolism also are discussed.

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Abbreviations

act:

actinorhodin

ACP:

Acyl Carrier Protein

NH4+:

ammonium ion

aphII:

aminoglycoside phosphotransferase gene

CoA:

Coenzyme A

dnr:

daunorubicin

hyg:

hygromycin phosphotransferase gene

PKS:

Polyketide Synthase

vdh:

valine dehydrogenase

tcm:

tetracenomycin

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  1. School of Pharmacy, University of Wisconsin, 53706, Madison, WI, USA

    C. Richard Hutchinson, Heinrich Decker, Krishnamurthy Madduri, Sharee L. Otten & Li Tang

  2. Department of Bacteriology, University of Wisconsin, 53706, Madison, WI, USA

    C. Richard Hutchinson

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  1. C. Richard Hutchinson
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  2. Heinrich Decker
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  3. Krishnamurthy Madduri
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  4. Sharee L. Otten
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  5. Li Tang
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Hutchinson, C.R., Decker, H., Madduri, K. et al. Genetic control of polyketide biosynthesis in the genusStreptomyces . Antonie van Leeuwenhoek 64, 165–176 (1993). https://doi.org/10.1007/BF00873025

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