Skip to main content
Log in

Amantadine in parkinsonian patients unresponsive to levodopa: a pilot study

  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Albin R, Young A, Penney J (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366–375

    PubMed  Google Scholar 

  2. Brooks DJ, Ibanez V, Sawle GV, Playford ED, Quinn N, Mathias CJ, Lees AJ, Marsden CD, Bannister R, Frackowiak RSJ (1992) Striatal D2 receptor status in Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with11C-raclopride and PET. Ann Neurol 31:184–192

    PubMed  Google Scholar 

  3. Carlsson M, Carlsson A (1989) The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J Neural Transm 75:221–226

    PubMed  Google Scholar 

  4. Colosimo C, Albanese A, Hughes AJ, de Bruin VMS, Lees AJ (1995) Some specific clinical features differentiate multiple system atrophy (striatonigral variety) from Parkinson's disease. Arch Neurol 52:294–298

    PubMed  Google Scholar 

  5. Fahn S, Elton RL, Agid Y, Barbeau A, Calne DB, Duvoisin RC, Hoehn MM, Jankovic J, Klawans HL, Lang AE, Lataste X, Lieberman AN, Marsden CD, Markham CH, Mayeux R, Rinne UK, Stern GM, Teychenne P, Yahr MD (1987) Unified Parkinson's disease rating scale. In: Fahn S, Marsden CD, Calne D, Goldstein M (eds) Recent developments in Parkinson's disease. MacMillan Healthcare Information, Florham Park, New Jersey, pp 153–163

    Google Scholar 

  6. Hughes AJ, Lees AJ, Stern GM (1990) Apomorphine test to predict dopaminergic responsiveness in parkinsonian syndromes. Lancet 336:32–34

    PubMed  Google Scholar 

  7. Hughes AJ, Colosimo C, Kleedorfer B, Daniel SE, Lees AJ (1992) The dopaminergic response in multiple system atrophy. J Neurol Neurosurg Psychiatry 55:1009–1013

    PubMed  Google Scholar 

  8. Kornhuber J, Bormann J, Hubers M, Rusche K, Riederer P (1991) Effects of the 1-amino-adamantanes at the MK801 binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study. Eur J Pharmacol 206:297–300

    PubMed  Google Scholar 

  9. Lees AJ (1987) The Steele-RichardsonOlszewski syndrome (progressive supranuclear palsy). In: Marsden CD, Fahn S (eds) Movement disorders 2. Butterworths, London, pp 272–287

    Google Scholar 

  10. Quinn N (1994) Multiple system atrophy. In: Fahn S, Marsden CD (eds) Movement disorders 3. ButterworthHeinemann, Oxford, pp 262–281

    Google Scholar 

  11. Riederer P, Kornhuber J, Gerlach M, Danielczyk W, Youdim MBH (1991) Glutamatergic-dopaminergic imbalance in Parkinson's disease and paranoid hallucinatory psychosis. In: Rinne UK, Nagatsu T, Horowski R (eds) How to proceed today in treatment. International workshop Berlin, Parkinson's disease. Medicom Europe, Bussum, pp 10–23 12. Riley D, Lang AE, Lewis A, Resch L, Ashby P, Homykiewicz O, Black J (1990) Cortical-basal ganglionic degeneration. Neurology 40:1203–1212

    Google Scholar 

  12. Stoof JC, Booij J, Drukarch B, Wolters EC (1992) The anti-parkinsonian drug amantadine inhibits theN-methyl-d-as-partic acid-evoked release of acetylcholine from rat neostriatum in a noncompetitive way. Eur J Pharmacol 213:439–443

    PubMed  Google Scholar 

  13. Von Voigtlander P, Moore K (1970) Dopamine: release from the brain in vivo by amantadine. Science 174:408–410

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Colosimo, C., Merello, M. & Pontieri, F.E. Amantadine in parkinsonian patients unresponsive to levodopa: a pilot study. J Neurol 243, 422–425 (1996). https://doi.org/10.1007/BF00869004

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00869004

Keywords

Navigation