Abstract
Urinary α1-microglobulin (U-A1M) was measured in healthy term infants on days 1, 4, 7, 14, 28, 90 and 180 of life. U-A1M was high until day 14 and declined thereafter. It was significantly correlated with urinary β2-microglobulin (U-B2M) throughout the study, but not with serum A1M on days 1 or 7. Similar to U-B2M, U-A1M in the clinically stable term infants with intrauterine growth retardation (n=4–7) was not elevated on days 1–7. In the sick infants who needed immediate resuscitatio at birth (n=4–8), U-A1M as well as U-B2M was high on days 1–7 and then decreased to normal levels, suggesting that U-A1M can be used as a sensitive marker of acute proximal tubular damage and its recovery. These observations indicate that U-A1M is a useful index of proximal tubular function in early infancy.
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References
Maack T, Johnson V, Kau ST, Figueiredo J, Sigulem D (1979) Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review. Kidney Int 16: 251–270
Karlsson FA, Hardell LI, Hellsing K (1979) A prospective study of urinary proteins in early infancy Acta Paediatr Scand 68: 663–667
Tack ED, Perlman JM, Robson AM (1988) Renal injury in sick newborn infants: a prospective evaluation using urinary β2-microglobulin concentrations. Pediatrics 81: 432–440
Davey PG, Gosling P (1982) 201-2 instability in pathological urine. Clin Chem 28: 1330–1333
Donaldson MDC, Chambers RE, Woolridge MW, Whicher JT (1989) Stability of alpha1-microglobulin, beta2-microglobulin and retinol binding protein in urine. Clin Chim Acta 179: 73–78
Yu H, Yanagisawa Y, Forbes MA, Cooper EH, Crockson RA, MacLennan ICM (1983) Alpha-1-microglobulin: an indicator protein for renal tubular function. J Clin Pathol 36: 253–259
Tohyama C, Kobayashi E, Saito H, Sugihara N, Nakano A, Mitane Y (1986) Urinary α1-microglobulin as an indicator protein of renal tubular dysfunction caused by environmental cadmium exposure. J Appl Toxicol 6: 171–178
Donaldson MDC, Chambers RE, Woolridge MW, Whicher JT (1990) Alpha1-microglobulin, beta2-microglobulin and retinol binding protein in childhood febrile illness and renal disease. Pediatr Nephrol 4: 314–318
Chevalier RL, Campbell F, Brenbridge ANAG (1984) Prognostic factors in neonatal acute renal failure. Pediatrics 74: 265–272
Hill J (1982) Evaluation of renal function in pediatrics. In: Hicks JM, Boeckx RL (eds) Pediatric clinical chemistry. Saunders, Philadelphia, pp 107–119
Zar JH (1984) Biostatistical analysis, 2nd edn. Prentice-Hall, New Jersey, pp 176–179, 201–202, 318–323
Oh W (1981) Renal functions and clinical disorders in the neonate. Clin Perinatol 8: 215–223
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Tsukahara, H., Hiraoka, M., Kurivama, M. et al. Urinaryα 1 as an index of proximal tubular function in early infancy. Pediatr Nephrol 7, 199–201 (1993). https://doi.org/10.1007/BF00864399
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DOI: https://doi.org/10.1007/BF00864399