References
Banerjee S, Wei BY, Hillman K, Luthra HS, David CS (1988) Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody. J Immunol 141:1150
Benjamin RJ, Waldmann H (1986) Induction of tolerance by monoclonal antibody therapy. Nature 320: 449
Boissier MC, Feng XZ, Carlioz A, Roudier R, Fournier C (1987) Experimental autoimmune arthritis in mice. I. Homologous type II collagen is responsible for self-perpetuating chronic polyarthritis. Anti Rheum Dis 46:691
Brahn E, Trentham DE (1984) Effect of antithymocyte serum on collagen arthritis in rats: evidence that T cells are involved in its pathogenesis. Cell Immunol 86:421
Brahn E, Peacock DJ, Banquerigo ML (1991) Suppression of collagen-induced arthritis by combination cyclosporin A and methotrexate therapy. Arthritis Rheum 34: 1282
Burmester GR, Yu DT, Irani AM, Kunkel HG, Winchester RJ (1981) Ia+T cells in synovial fluid and tissues of patients with rheumatoid arthritis. Arthritis Rheum 24:1370
Reference deleted
Calabrese LH, Wilke WS, Perkins AD, Tubbs RR (1989) Rheumatoid arthritis complicated by infection with the human immunodeficiency virus and the development of Sjogren's syndrome. Arthritis Rheum 32:1453
Cobbold SP, Jayasuriya A, Nash A, Prospero TD, Waldmann H (1984) Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312: 548
Cooper SM, Sriram S, Ranges GE (1988) Suppression of murine collagen-induced arthritis with monoclonal anti-la antibodies and augmentation with IFN-gamma. J Immunol 141:1958
Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B (1980) Immunisation against heterologous type II collagen induces arthritis in mice. Nature 283: 666
Daikh DI, Finck BK, Linsley PS, Hollenbaugh D, Wofsy D (1997) Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways. J Immunol 159:3104
Doncarli A, Stasiuk LM, Fournier C, Abehsira-Amar O (1997) Conversion in vivo from an early dominant Th0/Th1 response to a Th2 phenotype during the development of collagen-induced arthritis. Eur J Immunol 27: 1451
Durie FH, Fava RA, Foy TM, Aruffo A, Ledbetter JA, Noelle RJ (1993) Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 261:1328
Elliott MJ, Maim RN, Feldmann M, Long-Fox A, Charles P, Katsikis P, Brennan FM, Walker J, Bijl H, Ghrayeb J, Woody JN (1993) Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumour necrosis factor α. Arthritis Rheum 36:1681
Elliott MJ, Maim RN, Feldmann M, Kalden JR, Antoni C, Smollen JS, Leeb B, Breedfeld FC, Macfarlane JD, Bijl H, Woody JN (1994) Treatment with a chimaeric monoclonal antibody to tumour necrosis factor α suppresses disease activity in rheumatoid arthritis: results of a multi-centre, randomised, double blind trial. Lancet 344: 1105
Elliott MJ, Maim RN, Feldmann M, Long-Fox A, Charles P, Bijl H, Woody JN (1994) Repeated therapy with a monoclonal antibody to tumour necrosis factor α in patients with rheumatoid arthritis. Lancet 344: 1125
Emery P (1997) Prognosis in inflammatory arthritis: the value of HLA genotyping and the oncological analogy. J Rheumatol 24: 1436
Feldmann M, Brennan FM, Abney ER, Hales A, Chemajovsky Y, Katsikis P, Corcoran A, Haworth C, Cope A, Gibbons D, Chu CQ, Field M, Deleuran B, Williams RO, Maim RN (1994) Are imbalances in cytokine function of importance in the pathogenesis of rheumatoid arthritis? In: Davies ME, Dingle JT (eds) Immunopharmacology of joints and connective tissue. Academic Press, London, pp 119–128
Finck BK, Chan B, Wofsy D (1994) Interleukin 6 promotes murine lupus in NZB/NZW F1 mice. J Clin Invest 94: 585
Finck BK, Linsley PS, Wofsy D (1994) Treatment of murine lupus with CTLA4Ig. Science 265:1225
Firestein GS, Zvaifler NJ (1990) How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum 33:768
Galfre G, Milstein C, Wright B (1979) Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG. Nature 277: 131
Genain CP, Roberts T, Davis RL, Nguyen MH, Uccelli A, Faulds D, Li Y, Hedgpeth J, Hauser SL (1995) Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor. Proc Natl Acad Sci USA 92: 3601
Goldschmidt TJ, Holmdahl R (1991) Anti-T cell receptor antibody treatment of rats with established autologous collagen-induced arthritis: suppression of arthritis without reduction of anti-type II collagen autoantibody levels. Eur J Immunol 21:1327
Gregersen PK, Silver J, Winchester RJ (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30: 1205
Griggs ND, Agersborg SS, Noelle RJ, Ledbetter JA, Linsley PS, Tung KS (1996) The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells. J Exp Med 183: 801
Holmdahl R, Jansson L, Larsson E, Rubin K, Klareskog L (1986) Homologous type II collagen induces chronic and progressive arthritis in mice. Arthritis Rheum 29: 106
Holmdahl R, Andersson M, Enander I, Goldschmidt T, Jansson L, Larsson P, Mo J, Nordling C, Klareskog L (1988) Nature of the type II collagen autoimmunity in mice susceptible to collagen-induced arthritis. Int Rev Immunol 4: 49
Holmdahl R, Andersson ME, Goldschmidt TJ, Jansson L, Karlsson M, Malmström V, Mo J (1989) Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogenetics, pathogenesis and autoimmunity. APMIS 97:575
Hom JT, Butler LD, Riedl PE, Bendele AM (1988) The progression of the inflammation in established collagen-induced arthritis can be altered by treatments with immunological or pharmacological agents which inhibit T cell activities. Eur J Immunol 18: 881
Horsfall AC, Butler DM, Marinova L, Warden PJ, Williams RO, Maim RN, Feldmann M (1997) Suppression of collagen-induced arthritis by continuous administration of IL-4. J Immunol 159:5687
Jabs DA, Kuppers RC, Saboori AM, Burek CL, Enger C, Lee B (1994) Effects of early and late treatment with anti-CD4 monoclonal antibody on autoimmune disease in MRL/MP-lpr/lpr mice. Cell Immunol 154:66
Joosten LA, Lubberts E, Durez P, Helsen MM, Jacobs MJ, Goldman M, Van den Berg WB (1997) Role of interleukin-4 and interleukin-10 in murine collagen- induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction. Arthritis Rheum 40: 249
Kasama T, Stricter RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL (1995) Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest 95: 2868
Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PS, Winn, KJ, Persson TC (1996) Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381:434
Maeda T, Saikawa I, Hotokebuchi T, Sugioka Y, Eto M, Murakami Y (1994) Exacerbation of established collagen-induced arthritis in mice treated with an anti-T cell receptor antibody. Arthritis Rheum 37: 406
Maini RN, Elliott MJ, Brennan FM, Williams RO, Chu CQ, Paleolog E, Charles PJ, Taylor PC, Feldmann M (1995) Monoclonal anti-TNFα antibody as a probe of pathogenesis and therapy of rheumatoid arthritis. Immunol Rev 144:195
Maini RN, Breedveld FC, Kalden JR, Smolen IS, Davis D, Macfarlane JD, Antoni C, Leeb B, Elliott MJ, Woody JN, Schaible TF, Feldmann M (1997) Low dose methotrexate (MTX) suppresses anti-globulin responses and potentiates efficacy of a chimeric monoclonal anti-TNFα antibody (cA2) given repeatedly in rheumatoid arthritis (RA). Arthritis Rheum 40 [Suppl]: S 126
Malfait A-M, Butler DM, Presky DH, Maim RN, Brennan FM, Feldmann M (1998) Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis. Clin Exp Immunol 111: 377
Mauri C, Williams RO, Walmsley M, Feldmann M (1996) Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. Eur J Immunol 26: 1511
Mauri C, Chu CQ, Woodrow D, Mori L, Londei M (1997) Treatment of a newly established transgenic model of chronic arthritis with nondepleting anti-CD4 monoclonal antibody. J Immunol 159:5032
Mohan C, Shi Y, Laman JD, Datta SK (1995) Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J Immunol 154: 1470
Moreland LW, Heck LW, Koopman WJ (1997) Biologic agents for treating rheumatoid arthritis. Arthritis Rheum 40: 397
Nguyen DT, Eskandai MK, DeForge LE, Raiford CL, Strieter RM, Kunkel SL, Remick DG (1990) Cyclosporin A modulation of tumor necrosis factor gene expression and effects in vitro and in vivo. J Immunol 144:3822
Noelle RJ (1998) CD40 and its ligand in cell-mediated immunity. Agents Actions [Suppl] 49: 17
O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA (1992) FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357: 692
Oliver SJ, Cheng TP, Banquerigo ML, Brahn E (1995) Suppression of collagen-induced arthritis by an angiogenesis inhibitor, AGM-1470, in combination with cyclosporin: reduction of vascular endothelial growth factor (VEGF). Cell Immunol 166:196
Paulus HE, Machleder HI, Levine S, Yu DT, MacDonald NS (1977) Lymphocyte involvement in rheumatoid arthritis. Studies during thoracic duct drainage. Arthritis Rheum 20: 1249
Persson S, Mikulowska A, Narula S, O'Garra A, Holmdahl R (1996) Interleukin-10 suppresses the development of collagen type II-induced arthritis and ameliorates sustained arthritis in rats. Scand J Immunol 44:607
Piguet PF, Grau GE, Vesin C, Loetscher H, Gentz R, Lesslauer W (1992) Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor. Immunology 77: 510
Qin S, Cobbold S, Tighe H, Benjamin R, Waldmann H (1987) CD4 monoclonal antibody pairs for immunosuppression and tolerance induction. Eur J Immunol 17: 1159
Ranges GE, Sriram S, Cooper SM (1985) Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J Exp Med 162:1105
Rep MIL, Oosten BW van, Roos MT, Ader HJ, Polman CH, Lier RA van (1997) Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting Th1 cells in humans. J Clin Invest 99: 2225
Ross SE, Williams RO, Mason LJ, Mauri C, Marinova-Mutafchieva L, Malfait A-M, Maim RN, Feldmann M (1997) Suppression of TNF-α expression, inhibition of Thl activity, and amelioration of collagen-induced arthritis by rolipram. J Immunol 159:6253
Sheehan KC, Ruddle NH, Schreiber RD (1989) Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J Immunol 142: 3884
Sommer N, Loschmann PA, Northoff GH, Weller M, Steinbrecher A, Lichtenfels R, Meyermann R, Riethmuller A, Fontana A (1995) The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Nat Med 1: 244
Strober S, Kotzin B, Field E, Hoppe R, Myers B, Tanay A (1986) Treatment of autoimmune disease with total lymphoid irradiation. Cellular and humoral mechanisms. Ann N Y Acad Sci 475: 285
Taga T, Kishimoto T (1997) Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15:797
Tanaka Y, Otsuka T, Hotokebuchi T, Miyahara H, Nakashima H, Kuga S, Nemoto Y, Niiro H, Niho Y (1996) Effect of IL-10 on collagen-induced arthritis in mice. Inflamm Res 45:283
Thorbecke GJ, Shah R, Leu CH, Kuruvilla AP, Hardison AM, Palladino MA (1992) Involvement of endogenous tumor necrosis factor α and transforming growth factor β during induction of collagen type 11 arthritis in mice. Proc Natl Acad Sci USA 89:7375
Trentham DE (1982) Collagen arthritis as a relevant model for rheumatoid arthritis: evidence pro and con. Arthritis Rheum 25:911
Trentham DE, Townes AS, Kang AH (1977) Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 146: 857
Van Boxel JA, Paget SA (1975) Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med 293:517
Waldmann TA (1991) Monoclonal antibodies in diagnosis and therapy. Science 252:1657
Walmsley M, Katsikis PD, Abney E, Parry S, Williams RO, Maim RN, Feldmann M (1996) IL-10 inhibits progression of established collagen-induced arthritis. Arthritis Rheum 39:495
Webb LM, Walmsley ML, Feldmann M (1996) Prevention and amelioratrion of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2. Eur J Immunol 26:2320
Weyand CM, Hicok KC, Conn DL, Goronzy JJ (1992) The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 117: 801
Wiederrecht G, Lam E, Hung S, Martin M, Sigal N (1993) The mechanism of action of FK-506 and cyclosporin A. Ann N Y Acad Sci 696: 9
Williams RO, Feldmann M, Maim RN (1992) Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 89: 9784
Williams RO, Mason LJ, Feldmann M, Maim RN (1994) Synergy between anti-CD4 and anti-TNF in the amelioration of established collagen-induced arthritis. Proc Natl Acad Sci USA 91:2762
Williams RO, Ghrayeb J, Feldmann M, Maim RN (1995) Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4. Immunology 84:433
Williams RO, Mauri C, Mason LJ, Marinova-Mutafchieva L, Ross SE, Feldmann M, Maim RN (1998) Therapeutic actions of cyclosporin and anti-TNFα in collagen-induced arthritis and effect of combination therapy. Arthritis Rheum (in press)
Wooley PH, Luthra HS, Lafuse WP, Huse A, Stuart JM, David CS (1985) Type 11 collagen-induced arthritis in mice. III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera. J Immunol 134:2366
Yocum DE (1996) Cyclosporine, FK-506, rapamycin, and other immunomodulators. Rheum Dis Clin North Am 22: 133
Yoo TJ, Kim SY, Stuart JM, Floyd RA, Olson GA, Cremer MA, Kang AH (1988) Induction of arthritis in monkeys by immunization with type II collagen. J Exp Med 168:777
Yoshino S, Cleland LG (1992) Depletion of α/β T cells by a monoclonal antibody against the α/β T cell receptor suppresses established adjuvant arthritis, but not established collagen-induced arthritis in rats. J Exp Med 175: 907
Yoshino S, Cleland LG, Mayrhofer G (1991) Treatment of collagen-induced arthritis in rats with a monoclonal antibody against the alpha beta T cell antigen receptor. Arthritis Rheum 34: 1039
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Williams, R.O. Combination therapy in mice: what can we learn that may be useful for understanding rheumatoid arthritis?. Springer Semin Immunopathol 20, 165–180 (1998). https://doi.org/10.1007/BF00832005
Issue Date:
DOI: https://doi.org/10.1007/BF00832005