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Noncytolytic CD8 T cell-mediated suppression of HIV replication

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References

  1. Albert J, Gaines H, Sonnerborg A, Nystrom G, Pehrson PO, Chiodi F, Sydow M von, Moberg L, Lidman K, Christensson B (1987) Isolation of human immunodeficiency virus (HIV) from plasma during primary HIV infection. J Med Virol 23:67

    Google Scholar 

  2. Baier M, Werner A, Bannert N, Metzner K, Kurth R (1995) HIV suppression by interleukin-16. Nature 378:563

    Google Scholar 

  3. Barker TD, Weissman D, Daucher JA, Roche KM, Fauci AS (1996) Identification of multiple and distinct CD8+ T cell suppressor activites. J Immunol 156:4476

    Google Scholar 

  4. Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axer-Blin C, Vezinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolation of a T lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868

    Google Scholar 

  5. Biesinger B, Muller-Fleckenstein I, Simmer B, Lang G, Wittmann S, Platzer E, Desrosiers R, Fleckenstein B (1992) Stable growth transformation of human T lymphocytes by herpesvirus saimiri. Proc Natl Acad. Sci. USA 89:3116

    Google Scholar 

  6. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MBA (1994) Virus-specific CD8+ cytotoxic T lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 68:6103

    Google Scholar 

  7. Brinchmann JE, Gaudernack G, Thorsby E, Jonassen TO, Vartdal F (1989) Reliable isolation of human immunodeficiency virus from cultures of naturally infected CD4+ cells. J Virol Methods 25:293

    Google Scholar 

  8. Brinchmann JE, Gaudemack G, Vandal F (1990) CD8+ T cells inhibit HIV replication in naturally infected CD4+ cells. Evidence for a soluble inhibitor J Immunol 144:2961

    Google Scholar 

  9. Brinchmann JE, Gaudemack G, Vandal F (1991) In vitro replication of HIV-1 in naturally infected CD4+ T cells is inhibited by rIFN-α2 and by a soluble factor secreted by activated CD8+ T cells but not by rIFN-β, rIFN-γ, or by recombinant tumor necrosis factor-α. J Acquir Immune Defic Syndr 4:480

    Google Scholar 

  10. Buchbinder SP, Katz MH, Hessol NA, O'Malley PM, Holmberg SD (1994) Long-term HIV-1-infection without immunologic progression. J Acquir Immune Defic Syndr 8:1123

    Google Scholar 

  11. Cao Y, Qin L, Zhang L, Safrit J, Ho DD (1995) Virological and immunological characterization of long-term survivors of human immunodeficiency virus type I infection. N Engl J Med 332:201

    Google Scholar 

  12. Castro BA, Walker CM, Eichberg JW, and Levy JA (1991) Suppression of human immunodeficiency virus replication by CD8+ cells from infected and uninfected chimpanzees. Cell Immunol 132:246

    Google Scholar 

  13. Chen CH, Weinhold KJ, Bartlett JA, Bolognesi DP, Greenberg ML (1993) CD8+ T lymphocytemediated inhibition of HIV-1 long terminal repeat transcription: a novel antiviral mechanism. AIDS Res Hum Retrov 9:1079

    Google Scholar 

  14. Clark SJ, Saag MS, Decker WD, Campbell-Hill S, Roberson JL, Veldkamp PJ, Kappes JC, Hahn BH, Shaw GM (1991) High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1-infection N Engl J Med 324:954

    Google Scholar 

  15. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (1995) Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science; 270:1811

    Google Scholar 

  16. Conlon K, Lloyd A, Chattopadhyay U, Lukas N, Kunkel S, Schall T, Taub D, Morimoto C, Osborne J, Oppenheim J, Young H, Kelvin D, Ortaldo J (1995) CD8+ and CD45RA+ human peripheral blood lymphocytes are potent sources of macrophage inflammatory protein-1α, interleukin-8 and RANTES. Eur J Immunol 25:751

    Google Scholar 

  17. Coombs RW, Collier AC, Allain J-P, Mikora B, Leuther M, Gjerset GF, Corey L (1989) Plasma viremia in human immunodeficiency virus infection. N Engl J Med 321:1626

    Google Scholar 

  18. Copeland KFT, McKay PJ, Rosenthal KL (1995) Suppression of activation of the human immunodefiency virus long terminal repeat by CD8+ cells is not lentivirus specific. J Acquir Immune Defic Syndr Res Human Retroviruses 11:1321

    Google Scholar 

  19. Daar ES, Moudgil T, Meyer RD, Ho DD (1991) Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 324:961

    Google Scholar 

  20. Dalgleish AG, Beverly PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763

    Google Scholar 

  21. Deng HK, Choe S, Ellmeier W, Liu R, Unutmaz D, Burkhart M, Marzio PD, Marmon S, Sutton RE, Hill CM, Davis C, Peiper SC, Schall TJ, Littman DR, Landau NR (1996) Identification of a major coreceptor for entry of primary isolates of HIV-1. Nature 381:661

    Google Scholar 

  22. Dragic T, Litwin V, Allaway GP, Martin S, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA (1996) HIV-1 entry into CD4+ cells is mediated by the chemokine receptor C-C CKR-5. Nature 381:667

    Google Scholar 

  23. D'Souza MP, Mathieson BJ (1996) Early phases of HIV-1-infection: workshop summary. AIDS Res Hum Retrov 12:1

    Google Scholar 

  24. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K, Haase AT (1993) Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362:359

    Google Scholar 

  25. Ennen J, Findeklee H, Dittmar MT, Norley S, Ernst M, Kurth R (1994) CD8+ T lymphocytes of African green monkeys secrete an immunodeficiency virus-suppressing lymphokine. Proc Nat Acad Sci USA 91:7207

    Google Scholar 

  26. Eyster ME, Ballard JO, Gail MH, Drummond JE, Goedert JJ (1989) Predictive markers for the acquired immunodeficiency syndrome (AIDS) in hemophiliacs: persistence of p24 antigen and low T4 cell count. Ann Intern Med 110:963

    Google Scholar 

  27. Feng Y, Broder CC, Kennedy PE, Berger EA (1996) HIV-1 entry co-factor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science; 272:872

    Google Scholar 

  28. Gallo RC, Salahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, Palker TJ, Redfield R, Oleske J, Safai B, White G, Foster P, Markham PD (1984) Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224:500

    Google Scholar 

  29. Gomez AM, Smaill FM, Rosenthal KL (1994) Inhibition of HIV replication by CD8+ T cells correlates with CD4 counts and clinical stage of disease. Clin Exp Immunol 97:68

    Google Scholar 

  30. Ho DD, Moudgil T, Alam M (1989) Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. N Engl J Med 321:1621

    Google Scholar 

  31. Hogervorst E, Jurriaans S, Wolf F de, Wijk A van, Wiersma A, Valk M, Roos M, Gemen B van, Coutinho R, Miedema F, Goudsmit J (1995) Predictors for non- and slow progression in human immunodeficiency virus (HIV) type 1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels. J Infect Dis 171:811

    Google Scholar 

  32. Hsueh FW, Walker CM, Blackbourn DJ, Levy JA (1994) Suppression of HIV replication by CD8+ cell clones derived from HIV-infected and Uninfected individuals. Cell. Immunol. 159:271

    Google Scholar 

  33. Kannagi M, Chalifoux LV, Lord CI, Letvin NL (1988) Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes. J Immunol 140:2237

    Google Scholar 

  34. Kirchfoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC (1995) Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1-infection. N Engl J Med 332:228

    Google Scholar 

  35. Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, Gluckman J-C, Montagnier L (1984) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312:767

    Google Scholar 

  36. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD (1994) Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68:4650

    Google Scholar 

  37. Lacey SF, Chen C-H, Weinhold KJ, Greenberg ML (1995) Suppression of HIV-1 replication by primary and transformed CD8 cells. AIDS Res Human Retroviruses 11[Suppl]:S133

    Google Scholar 

  38. Learmont J, Tindall B, Evans L, Cunningham A, Cunningham P, Wells J, Penny R, Kaldor J, Cooper DA (1992) Long-term symptomless HIV-1-infection in recipients of blood products from a single donor. Lancet 340:863

    Google Scholar 

  39. Levy JA, Hoffman AD, Kramer SM, Landis JA, Shimabukuro JM, Oshiro LS (1984) Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science 225:840

    Google Scholar 

  40. Mackewicz CE, Ortega HW, Levy JA (1991) CD8 cell anti-HIV activity correlates with the clinical state of the infected individual. J Clin Invest 87:1462

    Google Scholar 

  41. Mackewicz CE, Ortega H, Levy JA (1994) Effect of cytokines on HIV replication in CD4+ lymphocytes: lack of identity with the CD8+ cell antiviral factor. Cell Immunol 153:329

    Google Scholar 

  42. Mackewicz CE, Blackbourn DJ, Levy JA (1995) CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription. Proc Natl Acad Sci USA 92:2308

    Google Scholar 

  43. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47:333

    Google Scholar 

  44. Mellors JW, Kingsley LA, Rinaldo CR Jr, Todd JA, Hoo BS, Kokka RP, Gupta P (1995) Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 122:573

    Google Scholar 

  45. Michael NL, Vahey M, Burke DS, Redfield RR (1992) Viral DNA and mRNA expression correlate with the stage of human immunodeficiency virus (HIV) type 1 infection in humans: evidence for viral replication in all stages of HIV disease. J Virol 66:310

    Google Scholar 

  46. Michael NL, Chang G, D'arcy LA, Ehrenberg PK, Mariani R, Busch MP, Birx DL, Schwartz DH (1995) Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus. J Virol 69:4228

    Google Scholar 

  47. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS (1993) HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355

    Google Scholar 

  48. Pantaleo G, Graziosi C, and Fauci AS (1993) Mechanisms of disease: the immunopathogenesis of human immunodeficiency virus infection. N Engl J Med 328:327

    Google Scholar 

  49. Pantaleo G, Menzo S, Vaccarezza M, Graziosi C, Cohen O, Demarest J, Montefiori D, Orenstein J, Fox C, Schrager L, Margolick J, Buchbinder S, Giorgi J, Fauci A (1995) Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med 332:209

    Google Scholar 

  50. Patterson BK, Till M, Otto P, Goolsby C, Furtado MR, McBride LJ, Wolinsky SM (1993) Detection of HIV-1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry. Science 260:976

    Google Scholar 

  51. Paxton WA, Martin SR, Tse D, O'brien TR, Skurnick J, VanDevanter NL, Padian N, Braun JF, Kotler DP, Wolinsky SM, Koup RA (1996) Relative resistance to HIV-1-infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nature Med 2:412

    Google Scholar 

  52. Piatak, Jr. M, Saag MS, Yang LC, Clark SJ, Kappes JC, Luk K-C, Hahn BH, Shaw GM, Lifson JD (1993) High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259:1749

    Google Scholar 

  53. Poli G, Fauci AS (1993) Cytokine modulation of HIV expression. Semin Immunol 5:304.1

    Google Scholar 

  54. Powell DJ, Bednarik DP, Folks TM, Jehuda-Cohen T, Villinger F, Sell KW, Ansari AA (1993) Inhibition of cellular activation of retroviral replication by CD8+ T cell derived from non-human primates. Clin Exp Immunol 91:473

    Google Scholar 

  55. Saksela K, Stevens C, Rubinstein P, Baltimore D (1994) Human immunodeficiency virus type 1 mRNA expression in peripheral blood cells predicts disease progression independently of the numbers of CD4+ lymphocytes Proc Natl Acad Sci USA 91:1104

    Google Scholar 

  56. Sheppard HW, Lang W, Ascher MS, Vittinghoff E, Winkelstein W (1993) The characterization of non-progressors: long-term HIV-1-infection with stable CD4+ T cell levels. J Acquir Immune Defic Syndr 7:1159

    Google Scholar 

  57. Tindall B, Cooper DA (1991) Primary HIV infection: host responses and intervention strategies. J Acquir Immune Defic Syndr 5:1

    Google Scholar 

  58. Toso JF, Chen C-H, Mohr JR, Piglia L, Oei C, Ferrari G, Greenberg ML, Weinhold KJ (1995) Oligoclonal CD8+ lymphocytes from asymptomatic HIV-infected individuals inhibit HIV-1 replication. J Infect Dis 172: (in press)

  59. Tsubota H, Lord CI, Watkins DI, Morimoto C, Letvin NL (1989) A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes. J Exp Med 169:1421

    Google Scholar 

  60. Walker BD, Plata F (1990) Cytotoxic T lymphocytes against HIV. J Acquir Immune Defic Syndr 4:177

    Google Scholar 

  61. Walker CM, Levy JA (1989) A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 66:628

    Google Scholar 

  62. Walker CM, Moody DJ, Stites DP, Levy JA (1986) CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234:1563

    Google Scholar 

  63. Walker CM, Thomson-Honnebier GA, Hsueh FC, Erickson AL, Pan L, Levy JA (1991) CD8+ cells from HIV-1-infected individuals inhibit acute infection by human and primate immunodeficiency viruses. Cell Immunol 137:420

    Google Scholar 

  64. Walker CM, Erickson AL, Hsueh FC, Levy JA (1991) Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a non-cytotoxic mechanism. J Virol 65:5921

    Google Scholar 

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  1. Department of Surgery, Duke University Medical Center, Box 2926, 27710, Durham, NC, USA

    Michael L. Greenberg, Simon F. Lacey, Chin-Ho Chen, Dani P. Bolognesi & Kent J. Weinhold

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Greenberg, M.L., Lacey, S.F., Chen, CH. et al. Noncytolytic CD8 T cell-mediated suppression of HIV replication. Springer Semin Immunopathol 18, 355–369 (1997). https://doi.org/10.1007/BF00813503

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