Amyloid resorption in the spleen grafted into intact and amyloid recipients

Abstract

Changes in amyloid spleens from CBA mice were studied when grafted into recipients of the following four groups: intact CBA mice, CBA mice with casein-induced amyloidosis, intact C57BL mice, and noninbred rats. Amyloid resorption in a syngeneic graft in recipients with amyloidosis was much less intensive than in intact animals. The intensity of amyloid resorption in intact recipients with syngeneic, allogeneic, and xenogeneic grafts increased with increasing heterogeneity of the transplanted material. The development of systemic amyloidosis (the so-called “transfer” of amyloidosis) was observed in some intact recipients after syngeneic transplantation of an amyloid spleen; the resorption of amyloid in the graft in these animals was less marked than in mice without “transfer.” Administration of hydrocortisone into animals with a syngeneic graft of an amyloid spleen completely inhibited amyloid resorption in the graft.