Abstract
On incubation of rabbit platelets with ADP, adrenalin, serotonin, and thrombin, the level of lipid hydroperoxides in the platelets, determined as malonic dialdehyde, increases parallel with the increased aggregative power. An even higher concentration of malonic dialdehyde is observed in the platelets of animals with pulmonary thrombosis. Dynamic studies showed that the accumulation of malonic dialdehydes in the platelets reflects the initial stage of development of thrombosis; this can be used for the diagnosis of the early stages of intravascular thrombosis.
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Kubatiev, A.A., Andreev, S.V. Lipid peroxides and thrombosis. Bull Exp Biol Med 87, 423–426 (1979). https://doi.org/10.1007/BF00806671
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DOI: https://doi.org/10.1007/BF00806671