Abstract
Experiments on dogs showed that splenectomy is followed by thrombocytosis, a decrease in the adhesive and aggregative properties of the platelets, and a decrease in their mean life span. The daily platelet production is increased and a study of the megakaryocytes showed a sharp shift toward mature forms. The number of megakaryocytes in the bone marrow was reduced. It is suggested that a factor controlling differentiation of the precursor cells of megakaryocytes is produced in the spleen.
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Abesadze, A.I., Bogvelishvili, M.V., Kvernadze, M.G. et al. Role of the spleen in the regulation of thrombocytopoiesis. Bull Exp Biol Med 86, 1648–1650 (1978). https://doi.org/10.1007/BF00801829
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DOI: https://doi.org/10.1007/BF00801829