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Alpha-fetoprotein synthesis in different lines of adult mice during regeneration of the liver

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The concentration of alpha-fetoprotein (AFP) in the sera of adult mice of 12 different lines and F1 hybrids of lines SWR and B10D2 was determined by radioimmunodiffusion in agar during regeneration of the liver after poisoning with CCl4. In the mice of 6 of 10 lines differences in the AFP concentration between females and males were statistically significant. Interlinear differences also were found: The mean AFP concentrations in the sera of inbred C57BL/6 and B10D2 mice were significantly lower than the corresponding values for mice of most other lines. The F1 hybrids were intermediate as regards their AFP concentration between the two parental lines. Small but statistically significant differences were found between groups of male F1 hybrids in direct and reciprocal corsses. It is suggested that induction of AFP synthesis during regeneration of the liver in adult mice is under polygenic control.

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Authors
  1. V. S. Poltoranina
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  2. T. V. Sorokina
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Poltoranina, V.S., Sorokina, T.V. Alpha-fetoprotein synthesis in different lines of adult mice during regeneration of the liver. Bull Exp Biol Med 86, 917–921 (1978). https://doi.org/10.1007/BF00801311

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  • DOI: https://doi.org/10.1007/BF00801311

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