Skip to main content
SpringerLink
Log in

Single mechanoreceptors (Pacinian corpuscles) studied by application of colchicine to the nerve

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

After application of colchicine to the caudal mesenteric nerve of cats, which contains sensory fibers for single mechanoreceptors (Pacinian corpuscles) the axon of the nerve endings degenerates. The character of the ultrastructural changes in the receptor is virtually identical with that observed during degeneration of axons after division of the nerve, but degeneration takes place much more slowly. The ultrastructural, electrophysiological, and biochemical changes taking place in the Pacinian corpuscles are not the result of the direct effect of the alkaloid, but are realized through the nerve, evidently by the blocking of axoplasmic transport. The results are evidence in support of the view that the structures of the receptor are under neurotrophic control by sensory neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. O. B. Il'inskii, G. N. Akoev, T. L. Krasnikova, et al., in: Biophysics of Membranes. Proceedings of a Symposium [in Russian], Kaunas (1971), pp. 409–419.

  2. O. B. Il'inskii and N. I. Chalisova, Usp. Sovrem. Biol.,80, 441 (1975).

    Google Scholar 

  3. E. G. Ulumbekov, in: Tissue Reception [in Russian], Leningrad (1974), pp. 160–168.

  4. E. X. Albuquerque, J. E. Warnick, J. R. Tasse, et al., Exp. Neurol.,37, 607 (1972).

    Google Scholar 

  5. O. A. Bessey, O. H. Lowry, and M. J. Brock, J. Biol. Chem.,164, 321 (1946).

    Google Scholar 

  6. A. J. Buller, J. C. Eccles, and R. M. Eccles, J. Physiol. (London),150, 417 (1960).

    Google Scholar 

  7. H. Chouchkov, Dokl. Bolgarsk. Akad. Nauk,21, 717 (1968).

    Google Scholar 

  8. C. N. Chouchkov, Z. Mikrosk.-Anat. Forsch.,83, 33 (1971).

    Google Scholar 

  9. M. Cuenod, P. Marko, E. Niederer, et al., in: Dynamics of Degeneration and Growth in Neurons (Proceedings of the International Symposium), Stockholm (1973), pp. 215–223.

  10. W. W. Hofmann and S. Thesleff, Eur. J. Pharmacol.,20, 256 (1972).

    Google Scholar 

  11. M. Singer and M. C. Steinberg, Am. J. Anat.,133, 51 (1972).

    Google Scholar 

  12. A. A. Zalewski, Ann. New York Acad. Sci.,228, 344 (1974).

    Google Scholar 

  13. J. Zelena, Prog. Brain Res.,13, 175 (1964).

    Google Scholar 

  14. J. Zelena, Prog. Brain Res.,43, 59 (1976).

    Google Scholar 

Download references

Authors
  1. Yu. A. Chelyshev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. I. Vinter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. R. Gataulin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chelyshev, Y.A., Vinter, R.I. & Gataulin, R.R. Single mechanoreceptors (Pacinian corpuscles) studied by application of colchicine to the nerve. Bull Exp Biol Med 86, 1265–1267 (1978). https://doi.org/10.1007/BF00800430

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00800430

Key Words

Search

Navigation