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Role of intermediate products of prothrombin proteolysis by thrombin in stimulation of the anticlotting system

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Two components were isolated from the products of proteolysis of prothrombin by immobilized thrombin: intermediate product 1 (P1) which, under suitable conditions, can be transformed into thrombin, and product 2 (P2), which does not have this property. After intravenous injection of P1 into rats the total clotting time and the plasma recalcification time were lengthened. The total fibrinolytic activity (TFA) and the level of fibrinogen degradation products were raised, the fibrinogen concentration was lowered, and the degree of nonenzymic fibrinolysis and its contribution to TFA rose sharply. Mobilization of the anticoagulant and fibrinolytic potential of the body was due to the response of the second anticlotting system. Intravenous injection of P2 or prothrombin into rats did not stimulate this system.

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Literature Cited

  1. T. M. Kalishevskaya, “Regulation relationships between the clotting and anticlotting systems of the blood,” Authors's Abstract of Doctoral Dissertation, Moscow (1968).

  2. T. M. Kovaleva, Vestn. Moskovsk. Univ., No. 5, 29 (1968).

    Google Scholar 

  3. B. A. Kudryashov, Usp. Fiziol. Nauk, No. 4, 17 (1970).

    Google Scholar 

  4. B. A. Kudryashov and L. A. Lyapina, Lab. Delo, No. 6, 326 (1971).

    Google Scholar 

  5. S. M. Strukova, Dokl. Akad. Nauk SSSR,225, 220 (1975).

    Google Scholar 

  6. T. Astrup and S. Mullertz, Arch. Biochem.,41, 346 (1952).

    Google Scholar 

  7. C. M. Heldebrant, R. J. Butkowski, S. P. Bajaj, et al., J. Biol. Chem.,248, 7149 (1973).

    Google Scholar 

  8. G. Lazar, Thrombos. Diathes. Haemorrh. (Stuttgart),17, 401 (1967).

    Google Scholar 

  9. L. B. Nanninga and M. M. Guest, Thrombos. Diathes. Haemorrh. (Stuttgart),17, 440 (1967).

    Google Scholar 

  10. W. H. Seegers, D. A. Walz, J. Reuterby, et al., Thromb. Res.,4, 829 (1974).

    Google Scholar 

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Authors
  1. B. A. Kudryashov
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  2. S. M. Strukova
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  3. A. S. Orlova
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  4. L. A. Lyapina
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Kudryashov, B.A., Strukova, S.M., Orlova, A.S. et al. Role of intermediate products of prothrombin proteolysis by thrombin in stimulation of the anticlotting system. Bull Exp Biol Med 82, 1462–1464 (1976). https://doi.org/10.1007/BF00799778

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  • DOI: https://doi.org/10.1007/BF00799778

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