Abstract
In experiments on dogs the assimilatory-excretory function of the liver was studied by means of the bromsulfthalein method in the intact animal and during perfusion of the isolated organ through the portal vein by means of an artificial circulation apparatus. Under perfusion conditions the rate of uptake of the dye was 50–60% of the value of this index in the intact animal. The rate of elimination of bromsulfthalein with the bile and the biliary plasma clearance in the intact animal were five to six times higher. The main cause of the reduction in the assimilatory-excretory function of the isolated liver is evidently hypoxia developing after denervation and removal of the organ from the body, and also during extracorporeal perfusion itself.
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Rozental', R.L., Tsimermane, G.I., Krivulis, D.B. et al. Assimilatory and excretory function of the isolated perfused dog liver. Bull Exp Biol Med 81, 489–491 (1976). https://doi.org/10.1007/BF00797546
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DOI: https://doi.org/10.1007/BF00797546