Influence of small intestine interoceptors on urinary excretion

Summary

The effect of water perfusion of a Thiry-Vella loop of small intestine was studied in three dogs in chronic preparations. As a rule, when urinary excretion was at the rapid rate of 2.1–1.5 ml per kg body weight per hr, it was increased by perfusion. The reaction was reflex in nature and was mediated from the mucous membrane of the perfused intestinal loop. This finding was confirmed by perfusing with a 2% novocain solution, when no rise in diuresis occurred.

The reflex from the mucous membrane of the small intestine on the kidneys depends largely on the initial functional condition of the drinking and food centers. Water perfusion of the isolated protion of the small intestine had no stimulating effect on diuresis either under conditions of food excitation or when the water content of the body was reduced.