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Heterogeneity of myocardial blood flow

  • Invited Contributions to the Symposium “Regulation of Coronary Blood Flow”, Held at the XV. World Congress of the International Society for Heart Research in Prague
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Abstract

Myocardial blood flow is heterogeneous, whether considered by chamber, by layers of the ventricular walls, or by microregions within layers. There is also variability of myocardial flow reserve, particularly in layers and microregions, even when the heart is arrested. The variability of flow during arrest may be associated with the resistance pathways to each region, but the variability of flows in the beating heart with vascular tone is probably due to regional differences in work and thus oxygen demand. Heterogeneity by layer may be responsible for the subendocardial ischemia that is common to many forms of heart disease. Microheterogeneity may account for the patchy necrosis that occurs with chronic ischemia.

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    J. I. E. Hoffman

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Invited Contributions to the Symposium “Regulation of coronary blood flow”, held at the XV. World Congress of the International Society for Heart Research in Prague 1995

Supported in part by Program Project Grant HL 25847 from the National Institute of Health

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Hoffman, J.I.E. Heterogeneity of myocardial blood flow. Basic Res Cardiol 90, 103–111 (1995). https://doi.org/10.1007/BF00789440

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