Summary
In experiments on the KB, HeLa and 709 tissue culture cells heparin was shown to inhibit the activity of the enzymes, especially of the cytochromoxidase and succindehydrogenase. The highest degree of inactivation was attained by a consecutive protector and heparin action upon the cells. Respiratory enzymes of the cells inhibited with heparin may be selectively reactivated with sodium persulfate (sulnat).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
L. L. Vannikov, Proceedings of the Second All-Union Oncological Conference [in Russian], Leningrad (1959). p. 503.
H. E. Alburn, and R. W. Whitbey, Fed. Proc., Vol. 13 Pt. 1 (1954), p. 330.
M. K. Horwitt, In book: J. H. Venable, Science, Vol. 102 (1945), p. 670.
S. Levey and S. Sheinfeld, Gastroenterology, Vol. 27 (1954), p. 625.
D. McClean, J. Path. Bact., Vol. 54 (1942), p. 284.
Silva M. rochae and S. O. Andrade, Science, Vol. 102 (1945), p. 670.
J. roth, Nature, Vol. 171 (1953), p. 127.
—, J. biol. Chem., Vol. 208 (1954), p. 181.
K. W. Walton, Brit. med. Bull., Vol. 11 (1955), p. 62.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shurin, S.P., Chasovskikh, G.G., Mikhailova, L.P. et al. Effect of heparin on malignant tumor cells in tissue culture. Bull Exp Biol Med 57, 332–336 (1964). https://doi.org/10.1007/BF00781921
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00781921