Abstract
New curare-like compounds of the diphenylethane series containing heterocyclic bis-ammonium groups have been synthesized: the di(methylbenzenesulfonate) derivative of p,p′-bispyrrolidino-1, 2-diphenylethane and p,p′-bispyrrolidino-meso-3,4-diphenylhexane. It has been shown that the reaction of the dimethiodide of p,p′-bis(dimethylamino)-meso-3,4-diphenylhexane (Paramion) with methyl benzenesulfonate forms the di(benzenesulfonic acid) analog.
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S. F. Topf and N. V. Khromov-Borisov, Med. Prom. SSSR, No. 6, 18 (1961).
A. I. Podlesnaya, Byull. éksper. Biol., No. 5, 78 (1963).
A. I. Podlesnaya, in the book: The Pharmacology of Neurotropic Substances [in Russian], Leningrad (1963), p. 215.
S. F. Topf and N. V. Khromov-Borisov, Zh. Obshch. Khim.,24, 1679 (1954).
S. Fried and R. D. Kleene, J. Am. Chem. Soc.,62, 3258 (1940).
S. F. Topf and N. V. Khromov-Borisov, Zh. Obshch. Khim.,26, 2785 (1956).
S. F. Topf and N. V. Khromov-Borisov, Med. Prom. SSSR, No. 6, 21 (1961).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 4, pp. 25–27, April, 1967.
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Topf, S.F., Cherepanova, V.P. Heterocyclic bis-ammonium derivatives of diphenylethane. Pharm Chem J 1, 199–200 (1967). https://doi.org/10.1007/BF00770188
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DOI: https://doi.org/10.1007/BF00770188