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Studies on a modified dextrane-ringer's-lactate mixture in intensive care patients

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Summary

The effects of a 1.8 % dextrane-Ringer's-lactate solution were tested on 16 critically ill patients in an Intensive Care Unit. The following variables were evaluated: Plasma expansion, circulatory effects, intravascular retention time of the colloid component and haemodilution as well as the impact of the solution on electrolyte balance, acid-base equilibrium, on diuresis, coagulation and carbohydrate metabolism. The tests showed that immediately following infusion a moderate rise in intravascular volume is registered that corresponds to about 1/2 to 1/3 of the volume administered. This effect disappeared after four hours. Negative impact on circulation, coagulation, electrolyte and acid-base balance was observed. The results are discussed in the light of experience gained with similar solutions by several other investigators. Possible improvements (e.g. higher dextrane concentration) were suggested. The use of the test solution for volume replacement (and possibly for treating shock acidosis) is generally admissible in less severe blood loss. It is recommended, however, to administer about 2–3 times the lost volume.

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Draxler, V., Wagner, H., Zekert, F. et al. Studies on a modified dextrane-ringer's-lactate mixture in intensive care patients. Europ. J. Intensive Care Med 1, 43–47 (1975). https://doi.org/10.1007/BF00735869

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