Abstract
We studied myelin proteins and glycolipids in 24 human oligodendrogliomas (16 pure, eight mixed), including two grade I, 13 grade II, five grade III, and four grade IV Tumours with a 1b ganglioside content (GD1b, GT1b and GQ1b) over 30% of total gangliosides occur more frequently in the WHO grade I II and (47%) and grade III (40%) than in the grade IV (25%) group; there was no difference in the amounts of total ganglioside or individual gangliosides between pure and mixed oligodendrogliomas. The presence of 6′-LM1 correlated with higher grades of tumours (χ2 p≃0.02); however, 3′-LM1 and total neolacto-series gangliosides did not correlate with grade. Immunohistochemical studies of oligodendrocyte and myelin markers (GalCer, sulfatide, 2′,3′-cyclic nucleotide phosphodiesterase, myelin basic protein and proteolipid protein) using specific antibodies showed only a very small proportion of tumour cells staining. These data do not support the hypothesis that tumours classified as oligodendrogliomas are derived from mature oligodendrocytes.
Similar content being viewed by others
References
Russel DS, Rubinstein LJ (1989)Pathology of Tumors of the Nervous System, Baltimore: Williams & Williams.
Bailey P, Cushing H (1926)A Classification of Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis. Philadelphia, London, Montreal: Lippincott.
Ogawa H, Sato Y, Takeshita I, Kitamura K (1985)Dev Brain Res 18: 133–41.
Choi BH, Kim RC (1984)Science 223: 407–9.
Herpers MJHM, Budka H (1984)Acta Neuropathol 64: 265–72.
Nakagawa Y, Perentes E, Rubinstein LJ (1986)Acta Neuropathol 72: 15–22.
Jagadha V, Halliday WC, Becker LE (1986)Can J Neurol Sci 13: 307–11.
Kamitani H, Masuzawa H, Sato J, Kanazawa I (1988)J Neurol Sci 83: 219–25.
Kros JM, De Jong AAW, Van Der Kwast TH (1992)J Neuropathol Exp Neurol 51: 186–93.
Bansal R, Pfeiffer SE (1992)J Neurosci Res 32: 309–16.
Myoga A, Taki T, Arai K, Sekiguchi K, Ikeda I, Kurata K, Matsumoto M (1988)Cancer Res 48: 1512–16.
Ledeen RW, Yu RK (1982)Methods Enzymol 83: 139–91.
Sung CC, Pearl DK, Coons SW, Scheithauer BW, Johnson PC, Yates AJ (1994)Cancer 74: 3010–22.
Folch J, Lees M, Sloane Stanley GH (1957)J Biol Chem 226: 497–509.
Saito T, Hakomori S-I (1971)J Lipid Res 12: 257–59.
Svennerholm L (1957)Biochim Biophys Acta 24: 604–11.
Miettinen T, Takki-Luukkainen IT (1959)Acta Chem Scand 13: 856–885.
Buehler J, Macher BA (1986)Anal Biochem 158: 283–87.
Li J, Pearl DK, Pfeiffer SE, Yates AJ (1994)J Neurosci Res 39: 148–58.
Kennedy PGE, Watkins BA, Thomas DGT, Noble MD (1987)Neuropathol Appl Neurobiol 13: 327–47.
Sung C-C, Pearl DK, Coons SW, Scheithauer BW, Johnson PC, Zheng M, Yates AJ (1995)Cancer 75: 851–59.
Singh LPK, Pearl DK, Franklin TK, Spring PM, Scheithauer BW, Coons SW, Johnson PC, Pfeiffer SE, Li J, Knott JCA, Yates AJ (1994)Mol Chem Neuropathol 21: 241–57.
Nojiri H, Stroud M, Hakomori S-I (1991)J Biol Chem 266: 4531–37.
Hakomori S (1990)J Biol Chem 265: 18713–16.
Hanai H, Nores GA, MacLeod C, Torres-Mendez C-R, Hakomori S-I (1988)J Biol Chem 263: 10915–21.
Paller AS, Arnsmeier SL, Alvarez-Franco M, Bremer EG (1993)J Invest Dermatol 100: 841–45.
Van Brocklyn J, Bremer EG, Yates AJ (1993)J Neurochem 61: 371–74.
Rabin SJ, Mocchetti I (1995)J Neurochem 65: 347–54.
Yates AJ, Saqr HE, Van Brocklyn J (1995)J Neuro-Oncol 24: 65–73.
Hakomori SI (1981)Annu Rev Biochem 50: 733–64.
Hakomori SI (1985) InMolecular Biology of Tumor Cells (Wahern B, Hammarstrom S, Holm G, Perlmann P, eds) p. 139–156. New York: Raven Press.
Figols J, Iglesias-Rozas JR, Kazner E (1985)Clin Neuropathol 4: 116–20.
Raff MC, Abney ER, Cohen J, Lindsay R, Noble M (1983)J Neurosci 3: 1289–1300.
Li Y, Atashi C, Hayes C, Reap S, Hunt S III, Popko B (1995)J Neurosci Res 40: 189–98.
Choi BH, Kim RC (1985)J Neuroimmunol 8: 215–35.
Min K-W, Scheithauer BW (1994)Ultrastruct Pathol 18: 47–60.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sung, C.C., Collins, R., Li, J. et al. Glycolipids and myelin proteins in human oligodendrogliomas. Glycoconjugate J 13, 433–443 (1996). https://doi.org/10.1007/BF00731476
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00731476