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Ceramide-1-phosphate sugars: new types of glycophospholipids

  • Glycoconjugate Journal
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Abstract

Ceramide-1-phosphate sugars were synthesized by direct glycosyl phosphite/phosphate andO-glycosyl trichloroacetimidate/phosphate exchange reactions, respectively. Thus, ceramide-1-O-phosphoric acid 5 gave with sialyl phosphite1 as sialyl donor directly β-linked sialyl phosphate6; deprotection afforded the corresponding glycophospholipid ceramide-1-phosphateN-acetylneuraminate7. Similarly, fromO-glucosyl- andO-galactosyltrichloroacetimidate10 and13 with phosphoric acid derivative5 glycosyl ceramide-1-phosphate sugars12 and15, respectively, were obtained.

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Authors and Affiliations

  1. Fakultät Chemie, Universität Konstanz, D-78434, Konstanz, Germany

    Thomas J. Martin, Gesche Dufner, Bernd Kratzer & Richard R. Schmidt

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  1. Thomas J. Martin
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  2. Gesche Dufner
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  3. Bernd Kratzer
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  4. Richard R. Schmidt
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Martin, T.J., Dufner, G., Kratzer, B. et al. Ceramide-1-phosphate sugars: new types of glycophospholipids. Glycoconjugate J 13, 547–553 (1996). https://doi.org/10.1007/BF00731442

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  • DOI: https://doi.org/10.1007/BF00731442

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