Summary
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1.
These experiments investigated the action of histamine on local inhibition in the CA1 region of thein vitro hippocampal slice preparation using a paired-pulse paradigm.
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We observed that histamine produced a concentration-dependent and reversible attenuation of paired-pulse inhibition. This effect was reduced by the H2 receptor antagonist, cimetidine, and mimicked by the H2 receptor agonist, impromidine.
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We also observed that histamine produced concentration-dependent effects on the amplitude of the population spike that could be correlated with alterations in the field excitatory postsynaptic potential (EPSP) amplitude and input fiber volley. High concentrations of histamine produced a reduction in the amplitude of the population spike which was always accompanied by a reduction in the EPSP and fiber volley amplitude.
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These results suggest that histamine, through the occupancy of H2 receptors, acts to modulate the efficacy of the local synaptic circuitry which is involved in producing paired-pulse inhibition in the hippocampus.
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References
Alger, B. E., and Nicoll, R. A. (1980). Epileptiform burst afterhyperpolarization: Calcium-dependent potassium potential in hippocampal CA1 pyramidal cells.Science 2101122–1124.
Alger, B. E., and Nicoll, R. A. (1982). Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studiedin vitro.J. Physiol. (Lond.)328105–123.
Anderson, P., and Lømo, J. (1969). Organization and frequency dependence of hippocampal inhibition. InBasic Mechanisms of the Epilepsies, H, (H. H. Jasper and A. A. Wards, Eds.), Little, Brown, Boston, pp. 604–609.
Anderson, P., Eccles, J. C., and Løyning, Y. (1964). Location of postsynaptic inhibitory synapses on hippocampal pyramids.J. Neurophysiol. 27592–607.
Barbin, G., Garbarg, M., Schwartz, J. C., and Storm-Mathesen, J. (1979). Histamine synthesizing afferents to the hippocampal region.J. Neurochem. 26259–263.
Dunwiddie, T. V., and Hoffer, B. J. (1980). Adenosine nucleotides and synaptic transmission in thein vitro rat hippocampus.Br. J. Pharmacol. 6959–68.
Garbarg, M., Barbin, G., Bischoff, S., Pollard, H., and Schwartz, J. C. (1976). Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area.Brain Res. 106333–348.
Geller, H. M., Springfield, S. A., and Tiberio, A. R. (1984). Electrophysiological actions of histamine.Can. J. Physiol. Pharmacol. 62715–719.
Green, J. P. (1970). InHandbook of Neurochemistry, Vol. 4 (A. Lajtha, Ed.), Plenum Press, New York.
Green, J. P., Johnson, C. L., and Weinstein, H. (1978). Histamine as neurotransmitter. InPsychopharmacology: A Generation of Progress (M. A. Lipton, A. DiMascio, and K. T. Killan, Eds.), Raven Press, New York.
Haas, H. L. (1981). Histamine hyperpolarizes hippocampal neuronsin vitro.Neurosci. Lett. 2275–78.
Haas, H. L., and Konnerth, A. (1983). Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells.Nature 302432–434.
Haas, H. L., and Wolf, P. (1977). Central actions of histamine: Microelectrode studies.Brain Res. 122269–279.
Haas, H. L., Schaerer, B., and Vosmansky, A. (1979). A simple perfusion chamber for the study of nervous tissue slicein vitro.J. Neurosci. Meth. 1 323–325.
Kandel, E. R., Spencer, W. A., and Brinkley, F. J. (1961). Electrophysiology of hippocampal neurons. I. Sequential invasion and synaptic organization.J. Neurophysiol. 24225–242.
Lee, K., and Schubert, M. (1982). Modulation of an inhibitory circuitry by adenosine and AMP in the hippocampus.Brain Res. 246311–314.
Lee, M., Strahlendorf, J. C., and Strahlendorf, H. K. (1986). Modulatory action of serotonin on glutamate-induced excitation of cerebellar purkinje cells.Brain Res. 361107–113.
Panula, P., Yang, H. Y., and Costa, E. (1984). Histamine-containing neurons in the rat hypothalamus.Proc. Natl. Acad. Sci. 812572–2576.
Pellmar, T. C. (1986). Histamine decrease calcium-mediated potassium current in guinea pig hippocampal CA1 pyramidal cells.J. Neuophysiol. 55727–738.
Sastry, B. S. R., and Phillis, J. W. (1976). Evidence for an ascending histaminergic pathway to the cerebral cortex.Can. J. Physiol. Pharmacol. 54782–786.
Schwartz, J. C. (1976). Histaminergic mechanisms in brain.Annu. Rev. Pharmacol. Toxicol. 17325–339.
Schwartz, J. C., Pollard, H., and Quach, T. T. (1980). Histamine as a neurotransmitter in mammalian brain: Neurochemical evidence.J. Neurochem. 3526–33.
Schubert, P., and Mitzdorf, A. (1979). Analysis and quantitative evaluation of the depressant effects of adenosine on evoked potentials in hippocampal slices.Brain Res. 172186–190.
Skrede, K., and Westgard, R. H. (1971). The transverse hippocampal slice: A well-defined cortical structure maintainedin vitro.Brain Res. 35589–593.
Segal, M. (1980a). The action of serotonin in the rat hippocampal slice preparation.J. Physiol. 303423–439.
Segal, M. (1980b). Histamine produces a Ca2+ sensitive depolarization of hippocampal pyramidal cellsin vitro.Neurosci. Lett. 1967–71.
Segal, M., and Bloom, F. E. (1976a). The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies.Brain Res. 7279–97.
Segal, M., and Bloom, F. E. (1976b). The action of norepinephrine in the rat hippocampus. IV. The effects of the locus coeruleus stimulation on evoked hippocampal unit activity.Brain Res. 107513–525.
Snyder, S. H., Brown, B., and Kuhar, M., (1974). The subsynaptosomal localization of histamine, histidine decarboxylase, and histamine-methyltransferase in rat hypothalamus.J. Neuochem. 2337–46.
Subramanian, N., and Mulder, A. (1977). Modulation by histamine of the efflux of radiolabelled catecholamines from rat brain slices.Eur. J. Pharmacol. 43143–152.
Taylor, K. M., and Snyder, S. H. (1973). The release of histamine from tissue slices of rat hypothalamus.J. Neurochem. 211215–1223.
Verdiere, M., Rose, C., and Schwartz, J. C. (1975). Synthesis and release of histamine on slices from rat hypothalamus.Eur. J. Pharmacol. 34157–168.
Watanbe, T., Taguguchi, Y., Shiosaka, S., Tanaka, J., Kubota, H., Terano, Y., Tohyama, M., and Wada, H. (1984). Distribution of the histaminergic neuron system in the central nervous system of rats: A fluorescent immunohistochemical analysis with histidine decarboxylase as a marker.Brain Res. 29513–25.
White, T. (1961). Some effects of histamine and two histamine metabolites on the cat's brain.J. Physiol. (Lond.). 159198–202.
Woodward, D. J., Moises, H. C., Waterhouse, B. D., Hoffer, B. J., and Freedman, R. (1979). Modulatory actions of norepinephrine in the central nervous system.Fed. Proc. 382109–2116.
Yamada, M., Tokimasa, T., and Koketsu, K. (1982). Effects of histamine on acetylcholine release in bullfrog sympathetic ganglia.Eur. J. Pharmacol. 8215–20.
Yamamoto, C., and McIlwain, H. (1966). Electrical activities in the thin sections from mammalian brain maintained in chemically defined mediain vitro.J. Neurochem. 131333–1343.
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Springfield, S.A., Geller, H.M. Histamine modulates local inhibition in the rat hippocampal slice. Cell Mol Neurobiol 8, 431–445 (1988). https://doi.org/10.1007/BF00711227
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DOI: https://doi.org/10.1007/BF00711227