Summary
A diabetic woman underwent an incision of the right big toe for an abscess and developed a typical Guillain-Barré syndrome 48 h later. A biopsy of a peripheral nerve, performed 10 days later, showed modifications usually seen in diabetic patients, as well as the characteristic ultrastructural modifications of the Guillain-Barré syndrome (GBS). Moreover, 22% of myelinated fibers exhibited vesicular disruption of the myelin sheaths. This lesion is rarely encountered on the biopsies of peripheral nerve in GBS and concerns only a few myelinated fibers. Such a prominence of myelinic vesicular disruption and its occurrence in a diabetic patient are discussed.
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Vital, C., Brechenmacher, C., Cardinaud, J.P. et al. Acute inflammatory demyelinating polyneuropathy in a diabetic patient: Predominance of vesicular disruption in myelin sheaths. Acta Neuropathol 67, 337–340 (1985). https://doi.org/10.1007/BF00687823
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DOI: https://doi.org/10.1007/BF00687823