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Localization of bulk stimuli underlying satiation inAplysia

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Summary

The present study was concerned with quantifying and localizing the bulk stimulus that causes satiation inAplysia.

  1. 1.

    Food-deprived animals were found to gain a mean of 15.4 ± 6.6 (S.D.) percent of body weight immediately following a meal of dried seaweed. The weight gain is largely accounted for by water ingested along with the dried seaweed (Fig. 3).

  2. 2.

    Animals that were chronically food deprived required a larger amount of food to satiate, compared to animals that had been fed daily (Figs. 7, 8; Table 1); nevertheless, after satiation, the mean anterior gut contents were similar in all animals, regardless of the quantity of bulk consumed during the meal (Figs. 8, 9). The greater quantity of food eaten by the previously food-deprived animals can be quantitatively accounted for by the smaller amount of bulk present in their anterior gut before the meal (Fig. 8).

  3. 3.

    Injection of high viscosity non-nutritive bulk which preferentially fills the anterior gut (Fig. 10) was capable of causing satiation (Figs. 11, 12), whereas injection of low viscosity bulk which preferentially fills the intestine did not cause satiation (Figs. 11, 12). Satiation also was not produced by injections of bulk into the hemocoel (Fig. 12).

The results suggest that satiation inAplysia is due to activation of mechanoreceptors associated solely with the anterior gut.

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Author notes

  1. Abraham J. Susswein

    Present address: Department of Physiology, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA

Authors and Affiliations

  1. Department of Physiology and Biophysics, New York University, School of Medicine, New York, USA

    Abraham J. Susswein & Irving Kupfermann

  2. New York State Psychiatric Institute, New York, USA

    Abraham J. Susswein & Irving Kupfermann

  3. Department of Physiology, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA

    Irving Kupfermann

Authors
  1. Abraham J. Susswein
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  2. Irving Kupfermann
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Additional information

We would like to thank Drs. T. Carew, V. Castellcci and E. Kandel for their comments on earlier drafts of this manuscript, S. Laskin for assistance in data analysis, and S. Hauser and K. Hilten for assistance with the illustrations. This research was supported by NINDS Grant 10757, by P.H.S. Predoctoral Training Grant to the Department of Physiology, N.Y.U. Medical School, 71176-234, and by Sloan Foundation 360-3070-2772.

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Susswein, A.J., Kupfermann, I. Localization of bulk stimuli underlying satiation inAplysia . J. Comp. Physiol. 101, 309–328 (1975). https://doi.org/10.1007/BF00657048

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