Abstract
A study was made of the effects of pretreatment with fractionated capsaicin on the changes in body temperature (Tb) induced in rats by exposure to cold and to warm environments, and by administration of histamine (40 mg·kg−1) or of pentobarbital (20 mg·kg−1) At the ambient temperature of 22 °C the Tb of capsaicin pretreated rats was lower than that of rats treated only with solvent (p<0.001). The capsaicin pretreated rats showed impairment of thermoregulation at both high and low environmental temperatures: their Tb rose to a higher level in a warm environment while in a cold environment their Tb was lower than that of the control rats. Histamine and pentobarbital caused larger drops in the Tb of capsaicin pretreated rats than in the controls. These findings challenge the concept that capsaicin treatment acts exclusively on thermoregulatory mechanisms concerned with warmth sensation.
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Bläsig J, Höllt V, Bauerle U, Herz A (1978) Involvement of endorphins in emotional hyperthermia of rats. Life Sci 23: 2525–2532
Briese E, Quijada de MG (1970) Colonic temperature of rats during handling. Acta physiol latinoamer 20: 97–102
Brück K, Wünnenberg W, Gallmeyer H, Ziehm B (1970) Shift of threshold temperature for shivering and heat polypnea as a mode of thermal adaptation. Pflügers Arch 321: 159–172
Cabanac M, Cormareche-Leydier M, Poirier LJ (1976) The effect of capsaicin on temperature regulation of the rat. Pflügers Arch 366: 217–221
Cormareche-Leydier M (1981) The effect of ambient temperature on rectal temperature, food intake and short term body weight in the capsaicin desensitized rat. Pflügers Arch 389: 171–174
Hori T, Harada Y (1977) The effect of capsaicin on behavioural thermoregulation. J Physiol Soc Japan 39: 266–267
Jancsó N (1965) Stimulation and desensitization of the heat-sensitive hypothalamic receptors by chemical agents. IIIrd Hung Conference on Therapy and Pharmacol Res 1964. Budapest, Akadémiai Kiadó, p 23–39
Jancsó-Gábor A, Szolcsányi J, Jancsó N (1970/a) Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs. J Physiol (Lond) 206: 495–507
Jancsó-Gábor A, Szolcsányi J, Jancsó N (1970/b) Stimulation and desensitization of the hypothalamic heat-sensitive structures by capsaicin in rats. J Physiol (Lond) 208: 449–459
Meeter E (1973) The functional significance of the cholinergic synaps responsible for carbachol hypothermia in the rat. In: Lomax P, Schönbaum E, Jacob J (eds) Temperature regulation and drug action. Karger, Basel, p 492–496
Nakayama T, Suzuki M, Ischikawa Y, Nishio A (1978) Effects of capsaicin on hypothalamic thermo-sensitive neurones in the rat. Neurosci Letters 7: 151–155
Obál F jr, Benedek G, Jancsó-Gábor A, Obál F (1979) Salivary cooling, escape reaction and heat pain in capsaicin-desensitized rats. Pflügers Arch 382: 249–254
Obál F jr, Benedek G, Jancsó-Gábor A, Obál F (1980) Tail skin vasodilatation and bath test in capsaicin-desensitized rats. Pflügers Arch 387: 183–188
Székely M, Szolcsányi J (1979) Endotoxin fever in capsaicin treated rats. Acta Physiol Acad Sci Hung 53: 469–477
Szikszay M, Benedek G, Obál F jr (1983) Capsaicin pretreatment interferes with the thermoregulatory effect of morphine. Pharmacol Biochem Behav 18: 373–378
Szolcsányi J, Jancsó-Gábor A (1875) Analysis of the role of warmth detectors by means of capsaicin under different conditions. In: Lomax P, Schönbaum E, Jacob J (eds) Temperature regulation and drug action. Karger, Basel, p 331–338
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Benedek, G., Szikszay, M. & Obál, F. Impaired thermoregulation against cold in capsaicin pretreated rats. Pflugers Arch. 399, 243–245 (1983). https://doi.org/10.1007/BF00656724
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DOI: https://doi.org/10.1007/BF00656724