Summary
Ten fasting subjects received 200 mg cimetidine orally either with water or 11 g aluminium phosphate mixture in a randomized, single dose, two-way cross-over study. Blood samples were taken for 12 h and urine was collected for 24 h. Cimetidine in plasma and urine was analysed by HPLC. There were no significant differences between the treatments with respect to peak plasma concentration, time to peak plasma concentration, area under the plasma concentration-time curve, and urinary excretion. In 12 healthy subjects the absorption of prednisolone was investigated when given alone and together with 11 g aluminium phosphate. Blood samples were taken over 16 h and prednisolone in plasma was analysed by HPLC. There were no significant differences in the values of area under curve (AUC), Cmax and tmax. The results indicate that aluminium phosphate does not reduce the bioavailability of cimetidine and prednisolone.
This is a preview of subscription content, log in via an institution to check access.
References
Albin H, Vinçon G, Bertolaso D, Dangoumau J (1981) Influence du phosphate d'aluminium sur la biodisponibilité de la procaïnamide et du disopyramide. Therapie 36: 541–546
Bodemar G, Normander B, Walan A (1979) Diminished absorption of cimetidine caused by antacid. Lancet 1: 444–445
Bodemar G, Mills JG, Norlander B, Osborne P, Burland WL, Walan A (1978) Effects of antacids on the absorption of cimetidine. Gut 19: 990
Brazier JL, Tamisier JN, Ambert D, Bannier A (1981) Bioavailability of ketoprofen in man with and without concomitant administration of aluminium phosphate. Eur J Clin Pharmacol 19: 305–307
Burland WL, Darkin DW, Mills MW (1976) Effects of antacids on absorption of cimetidine. Lancet 2: 965
Gugler R, Brand M, Somogyi A (1981) Impaired cimetidine absorption due to antacids and metoclopramide. Eur J Clin Pharmacol 20: 225–228
Hurwitz A (1977) Antacid therapy and drug kinetics. Clin Pharmacokinet 2: 269–280
Lambert T, Minaire Y (1977) Le traitment antiacide de l'ulcère gastroduodénal Gastroenterol. Clin Biol 1: 3–7
Lee DHA, Taylor GM, Walker JG, James VHT (1979) The effect of concurrent administration of antacids on prednisolone absorption. Br J Clin Pharmacol 8: 92–94
Loo JCK, Butterfield AG, Moffatt J, Jordan N (1977) Analysis of prednisolone in plasma by high-performance liquid chromatography. J Chromatogr 143: 275–280
Randolf WC, Osborne VL, Walkenstein S, Intoccia AP (1977) High-pressure liquid chromatographic analysis of cimetidine a histamine H2receptor antagonist in blood and urine. J Pharm Sci 66: 1148–1150
Steinberg WM, Lewis JH (1980) Mylanta II inhibits the absorption of cimetidine. Gastroenterology 78: 1269
Steinberg WM, Lewis JH, Katz DM (1982) Antacids inhibit absorption of cimetidine N Engl J Med 307: 400–407
Tanner AR, Caffin JA, Halliday JW, Powell LW (1979) Concurrent administration of antacids and prednisone: effect on serum levels of prednisolone. Br J Clin Pharmacol 7: 397–400
Uribe M, Casian C, Rojas S, Sierra JG, Go VLW (1981) Decreased bioavailability of prednisone due to antacids in patients with chronic active liver disease and in healthy volunteers. Gastroenterology 80: 661–665
Wagner JG (1975) Fundamentals of clinical pharmacokinetics. First edn. In: Wagner JG (ed) Drug Intelligence Publications, Hamilton, Illinois, USA
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Albin, H., Vinçon, G., Demotes-Mainard, F. et al. Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone. Eur J Clin Pharmacol 26, 271–273 (1984). https://doi.org/10.1007/BF00630299
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00630299