Abstract
With the aim of obtaining antitumoral drugs possessing a binary action mechanism, we have synthesized a series of shortened analogs of luliberin, including some containing a 1-carboxymethyl-5-fluorouracil residue. Their antitumoral and hormonal activities have been investigated.
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References
F. Labrie, A. Belanger, and A. Dupont, LHRH and its Analogues. Basic and Clinical Aspects, Excerpta Medica, Amsterdam (1984).
M. Fekete, S. Bajusz, K. Groot, V. J. Csernus, and A. V. Shally, Endocrinology,124, 946 (1989).
S. Bajusz, T. Janaky, V. J. Csernus, L. Bokser, M. Fekete, G. Srkalonic, T. Z. Redding, and A. V. Shally, Proc. Natl. Acad. Sci. USA,86, 6316, 6318 (1989).
Y. Ike, H. Mizuno, K. Ishikawa, H. Mori, and S. Okazi, Bull Chem. Soc. Jpn.,50, 2406 (1977).
T. Ouchi, H. Yuyama, and O. Vogl, J. Polym. Sci.: Polym Lett. Ed.,25, 279 (1987).
H. Pischel, A. Holy, and G. Wagner, Coll. Czech Chem. Commun.,44, 1634 (1979).
S. V. Burov, S. V. Nikolaev, M. P. Smironova, G. E. Lupanova, Yu. F. Bobrov, A. M. Nevolin-Lopatin, and É. M. Kitaev, Khim. Prir. Soedin., 672 (1982).
G. P. Vlasov, S. V. Burov, T. V. Semko, O. S. Veselkina, and M. F. Makusheva, in: Peptides 1990, E. Giralt and D. Andreu (eds.), ESCOM Scientific Publishers B.V., Leiden (1991), p. 682
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Institute of High-Molecular-Mass Compounds, Russian Academy of Sciences, St. Petersburg. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 655–662, September–October, 1994.
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Semko, T.V., Burov, S.V., Veselkina, O.S. et al. Synthesis and investigation of the antitumoral activity of shortened analogs of luliberin. Chem Nat Compd 30, 607–612 (1994). https://doi.org/10.1007/BF00629874
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DOI: https://doi.org/10.1007/BF00629874