Summary
2,5-Anhydro-d-mannitol with a fixed furanose ring stimulated the sugar receptor of the flesh fly (Fig. 1) and reacted with the furanose site (Fig. 3). This is the first direct evidence that a furanose can stimulate the sugar receptor and supports strongly the assumption thatβ-d-fructofuranose is the only stimulatory component in the solution ofd-fructose.
Rigid stereospecificity of the furanose site in the sugar receptor is discussed according to the effectiveness of various synthetic 2,5-anhydro-d-hexitols and related compounds (Table 2, Fig. 6).
At least four receptor sites are concluded to be in a single sugar receptor: a pyranose (P) site, a furanose (F) site, an aliphatic carboxylate (R) site and an aromatic amino acid (Ar) site.
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Shimada, I., Horiki, H., Ohrui, H. et al. Taste response to 2,5-anhydro-d-hexitols; rigid stereospecificity of the furanose site in the sugar receptor of the flesh fly. J. Comp. Physiol. 157, 477–482 (1985). https://doi.org/10.1007/BF00615148
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DOI: https://doi.org/10.1007/BF00615148