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Renal response to infusion versus repeated bolus injections of atrial natriuretic factor in man

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Summary

In 7 healthy humans consuming a 170 mmol sodium diet the effect of the mode of administration of atrial natriuretic factor (human ANF 99–126) on renal function has been investigated, using conventional clearance studies during maximal water diuresis. ANF was administered as four repeated bolus (0.4 µg/kg) injections and, after a 2-day interval, as a one-hour infusion (0.02 µg/kg/min) preceded by a 0.4 µg/kg bolus injection.

In the two experiments ANF caused comparable elevations in glomerular filtration rate, free water clearance, and lithium excretion. No change in blood pressure or heart rate was observed in either study, and plasma renin activity and aldosterone fell by a similar extent.

As expected, the time course of plasma ANF concentrations was markedly different during the two studies. It is concluded that with those doses of ANF the changes in renal haemodynamics and sodium handling were essentially similar after bolus injections and a constant infusion.

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References

  1. Burnett JC, Granger JP, Opgenorth TJ (1984) Effects of synthetic atrial natriuretic factor on renal function and renin release. Am J Physiol 247: F863-F866

    PubMed  CAS  Google Scholar 

  2. Maack T, Marion DN, Camargo MJF, Kleinert HD, Laragh JH, Vaughan ED, Atlas SA (1984) Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function and the renin-aldosterone system in dogs. Am J Med 77: 1069–1075

    Article  PubMed  CAS  Google Scholar 

  3. Richards AM, Ikram H, Yandle TG, Nicholls MG, Webster MWI, Espiner EA (1985) Renal, haemodynamic, and hormonal effects of human alpha-atrial natriuretic peptide in healthy volunteers. Lancet 1: 545–549

    Article  PubMed  CAS  Google Scholar 

  4. Cody RJ, Atlas SA, Laragh JH (1987) Physiologic and Pharmacologic studies of atrial natriuretic factor: a natriuretic and vasoactive peptide. J Clin Pharmacol 27: 927–936

    PubMed  CAS  Google Scholar 

  5. Maack T (1986) Renal clearance and isolated kidney perfusion techniques. Kidney Int 30: 142–151

    PubMed  CAS  Google Scholar 

  6. Gaillard CA, Koomans HA, Rabelink AJ, Dorhout Mees EJ (1987) Effects of indomethacin on renal response to atrial natriuretic peptide. Am J Physiol 253: F868-F873

    PubMed  CAS  Google Scholar 

  7. Gaillard CA, Koomans HA, Dorhout Mees EJ (1988) Enalapril attenuates natriuresis of atrial natriuretic factor in humans. Hypertension 11: 160–165

    PubMed  CAS  Google Scholar 

  8. Heyrowski A (1956) A new method for the determination of inulin in plasma and urine. Clin Chim Acta 1: 470–474

    Article  Google Scholar 

  9. Waugh WH, Beall PT (1974) Simplified measurement of p-aminohippurate and other arylamines in plasma and urine. Kidney Int 5: 429–436

    PubMed  CAS  Google Scholar 

  10. Boer P, Hene RJ, Koomans HA, Nieuwenhuis MG, Geyskes GG, Dorhout Mees EJ (1983) Blood and extracellular fluid volume in patients with Bartter's syndrome. Arch Intern Med 143: 1902–2052

    Article  PubMed  CAS  Google Scholar 

  11. Schuster VL, Seldin DW (1985) Renal clearance. In: Seldin DW, Giebisch G (eds) The kidney, physiology and pathophysiology. Raven Press, New York, pp 396–397

    Google Scholar 

  12. Thomsen K (1984) Lithium clearance; a new method for determining proximal and distal tubular reabsorption of sodium and water. Nephron 37: 217–223

    Article  PubMed  CAS  Google Scholar 

  13. Snedecor GW, Cochran WG (1967) Statistical methods, 6th edn. Iowa State University Press, Ames, pp 271–275

    Google Scholar 

  14. Biollaz J, Bidiville J, Diézi J, Waeber B, Nussberger J, Brunner-Ferber F, Gomez HJ, Brunnér HR (1987) Site of the action of a synthetic atrial natriuretic peptide evaluated in humans. Kidney Int 32: 537–546

    PubMed  CAS  Google Scholar 

  15. Brier ME, Brier RA, Luft FC, Aronoff GR (1987) Kinetics and pharmacodynamics of atrial natriuretic peptide and lithium clearance in the isolated perfused rat kidney. J Pharmacol Exp Ther 243: 868–873

    PubMed  CAS  Google Scholar 

  16. Gnädinger MP, Lang RE, Hasler L, Uehlinger DE, Shaw S, Weidman P (1986) Plasma kinetics of synthetic alpha-human atrial natriuretic peptide in man. Min Electrolyte Metab 12: 371–374

    Google Scholar 

  17. Anderson JV, Donckier J, Payne NN, Beacham J, Slater JDH, Bloom SR (1987) Atrial natriuretic peptide: Evidence of action as a natriuretic hormone at physiological plasma concentrations in man. Clin Sci 72: 305–312

    PubMed  CAS  Google Scholar 

  18. Cody RJ, Atlas SA, Laragh JH, Kubo SA, Covit AB, Ryman KS, Shaknovich A, Pondolfino K, Clark M, Camargo MJF, Scarborough RM, Lewicki JA (1986) Atrial natriuretic factor in normal subjects and heart failure patients. J Clin Invest 78: 1362–1374

    Article  PubMed  CAS  Google Scholar 

  19. Cuneo RS, Espiner EA, Nicholls MG, Yandle TG, Joyce SL, Gilchrist NL (1986) Ranel, hemodynamic and hormonal responses to atrial natriuretic peptide infusions in normal man and effect of sodium intake. J Clin Endocrinol Metab 63: 946–953

    Article  PubMed  CAS  Google Scholar 

  20. Weder AB, Sekkarie MA, Takiyyuddin M, Schork NJ, Julius S (1987) Antihypertensive and hypotensive effects of atrial natriuretic factor in men. Hypertension 10: 582–589

    PubMed  CAS  Google Scholar 

  21. Petrillo A, Scherrer U, Gonvers JJ, Nussberger J, Marder H, de Vane P, Waeber B, Hofstetter JR, Brunner HR (1987) Atrial natriuretic peptide (ANP) in cirrhotic patients: Bolus injections versus infusions (abstract). Programme and Abstracts of Second World Congress on Biologically Active Atrial Peptides. The American Society of Hypertension, New York 1987, p 223

    Google Scholar 

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Authors and Affiliations

  1. Departments of Nephrology and Hypertension, University Hospital, Utrecht, The Netherlands

    C. A. Gaillard, H. A. Koomans, A. J. Rabelink, P. Boer & E. J. Dorhout Mees

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  1. C. A. Gaillard
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  2. H. A. Koomans
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  3. A. J. Rabelink
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  4. P. Boer
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  5. E. J. Dorhout Mees
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Gaillard, C.A., Koomans, H.A., Rabelink, A.J. et al. Renal response to infusion versus repeated bolus injections of atrial natriuretic factor in man. Eur J Clin Pharmacol 36, 195–197 (1989). https://doi.org/10.1007/BF00609194

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  • DOI: https://doi.org/10.1007/BF00609194

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