Summary
To compare the clinical and metabolic effects of a new diuretic uricosuric agent, tienilic acid, with those of hydrochlorothiazide, a multicentre double-blind trial was performed in 56 hypertensive patients. Twenty — eight patients were randomly assigned to take tienilic acid and 28 to take hydrochlorothiazide. The diuretic and anti-hypertensive actions of the two compounds were similar. No significant differences were observed between tienilic acid and hydrochlorothiazide in their effects on urinary and serum electrolytes, hepatic and renal function tests, and fasting lipids. The patients who received tienilic acid showed a significant fall in serum uric acid, mediated by the uricosuric effect. The availability of an agent combining diuretic, anti-hypertensive and hypouricemic effects offers promise in the treatment of arterial hypertension.
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Bolli, P., Simpson, O., Waal-Manning, H.J.: Comparison of tienilic acid with cyclopenthiazide in hyperuricaemic hypertensive patients. Lancet1978/II, 595–598
Breckenridge, A.: Hypertension and hyperuricaemia. Lancet1966/I, 15–18
Cannon, P. J., Statson, W. B., De Martini, F. E., Summers, S. C., Laragh, J. H.: Hyperuricemia in primary and renal hypertension. N. Engl. J. Med.275, 457–464 (1966)
Hull, A. R., Suki, W., Rector, F., Seldin, D.: Mechanism action of hyperuricemia induced by diuretic agents. Am. J. Med.32, 572–583 (1967)
Lau, K., Stote, R. M., Goldberg, M., Agus, Z. S.: Mechanism of the uricosuric affect of the diuretic tienilic acid (Ticrynafen) in man. Clin. Sci. Mol. Med.53, 379–386 (1977)
Lemieux, G., Gougoux, A., Vinay, P., Kiss, A., Baverel, G.: Metabolic effects in man of tienilic acid, a new diuretic with uricosuric properties. Nephron20, 54–64 (1978)
Lemieux, G., Kiss, A., Vinay, P., Gougoux, A.: Nature of the uricosuric effect of tienilic acid, a new diuretic. Kidney Int.12, 104–114 (1977)
Masbenard, A., Giudicelli, C. P.: Etude clinique de l'action anti-hypertensive de l'acide chloro-2,3(thiényl-2-céto)-phénoxiacetique en administration prolongée. Lyon Med.232, 165–174 (1974)
Masbenard, A., Giudicelli, C. P., Kamaludin, T.: Etude pharmacologique clinique de l'acide dichloro-2,3(thiényl-2-céto)-phénoxiacetique. J. Pharmacol. Clin. Special Issue, pp. 13–18 (1976)
Nadal, M. A., Bermudez, J., Yeyati, N., Barrera, L. A., Gotlieb, D.: Clinical trial with tienilic acid in patients with primary and secondary arterial hypertension. Curr. Ther. Res.23, 286–293 (1978)
Nemati, M., Kyle, M. C., Freis, E. D.: Clinical study in Ticrynafen. A new diuretic, anti-hypertensive and uricosuric agent. J. Am. Med. Assoc.237, 652–657 (1977)
Reese, O. G., Jr., Steel, T. H.: Renal transport of urate during diuretic induced hypouricemia. Am. J. Med.60, 973–979 (1976)
Roger, E., Kirk, A.: Experimental design: procedures for the behavioral sciences. Belmont: Brooks Cole 1968
Stote, R. M., Cherrill, D. A., Erb, B. B., Alexander, F.: Site of action of SK$F 62698 (ANP 3624) a new diuretic uricosuric agent. Clin. Res.22, 721 (abstract) (1974)
Talbott, J. H., Terplan, K. L.: The kidney in gout. Medicine (Baltimore)39, 405–467 (1960)
Thuillier, G., Laforest, J., Cariou, B., Bessin, P., Bonnet, J., Thuiller, J.: Dérivés hétérocycliques d'acides phénoxy-acétiques: Synthèse et étude préliminaire de leur activité diurétique et uricosurique. Eur. J. Med. Chem.9, 625–633 (1974)
Vargas, R., Ryan, J. J., Mac Mahon, F. G.: The diuretic treatment of mild hypertension with ticrynafen (T) or hydrochlorothiazide. Clin. Pharmacol. Ther.21, 119–120 (1977)
Verger, D., Leroux-Robert, C., Ganter, P., Richet, G.: Les tophus goutteux de la médullaire rénale des urémiques chroniques: étude de 17 cas découverts au cours de 62 autopsies. Nephron4, 356–362 (1967)
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Ponticelli, C., Lechi, A., di Perri, T. et al. Multicentre comparative trial of tienilic acid and hydrochlorothiazide in hypertensive patients. Eur J Clin Pharmacol 16, 319–322 (1979). https://doi.org/10.1007/BF00605628
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DOI: https://doi.org/10.1007/BF00605628